Disseminated Oligodendroglial-like Leptomeningeal Tumor in the Adult: Case Report and Review of the Literature

Pietro Fiaschi, Filippo Badaloni, Bernarda Cagetti, Luca Bruzzone, Gianluca Marucci, Anna Dellachà, Marco Pavanello, Giuseppe Ganci, Riccardo Padolecchia, Valtero Valsania

Research output: Contribution to journalReview article

Abstract

Background: Diffuse leptomeningeal glioneuronal tumor (DLGNT) was recently added to the World Health Organization classification of central nervous system tumors. DLGNT is a rare entity that occurs more commonly in pediatric patients, but occasional cases have been reported in adults. This tumor has been recognized as a distinct pathologic entity; however, its biologic behavior remains unclear. It is considered an indolent neoplasm, although considerable morbidity has been reported. For this reason, further characterization and collection of evidence are crucial. Methods: In this article, we reported a case of a 36-year-old woman with a DLGNT characterized by rapid, aggressive behavior. We also performed a review of the literature for reported cases of low-grade and high-grade forms involving adults and children. Results: DLGNTs should no longer be considered only as low-grade tumors affecting pediatric patients. The spectrum of presentations also includes aggressive tumors affecting adults. Conclusions: Further clinical and pathologic data supported by cytogenetic and molecular investigations are mandatory to better characterize DLGNTs.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalWorld Neurosurgery
Volume114
DOIs
Publication statusPublished - Jun 1 2018

Keywords

  • Adult leptomeningeal tumor
  • Disseminated
  • Oligodendroglial-like
  • Oligodendroglioma
  • Tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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    Fiaschi, P., Badaloni, F., Cagetti, B., Bruzzone, L., Marucci, G., Dellachà, A., Pavanello, M., Ganci, G., Padolecchia, R., & Valsania, V. (2018). Disseminated Oligodendroglial-like Leptomeningeal Tumor in the Adult: Case Report and Review of the Literature. World Neurosurgery, 114, 53-57. https://doi.org/10.1016/j.wneu.2018.02.160