Dissociated 24-Hour patterns of somatotropin and prolactin in fatal familial insomnia

Francesco Porialuppi, Pietro Cortelli, Patrizia Avoni, Luciana Vergnani, Paolo Maltoni, Anna Pavani, Emilia Sforza, Roberto Manfredini, Pasquale Montagna, Ignazio Roiter, Pierluigi Gambetti, Carmelo Fersini, Elio Lugaresi

Research output: Contribution to journalArticlepeer-review


To assess the changes in the 24-hour profiles of serum somatotropin and prolactin levels during total disruption of the sleep/wake cycle sustained over several months, we studied 2 subjects affected by fatal familial insomnia, a rare disease characterized by selective thalamic degeneration that causes chronic sleep loss. Under standardized conditions and polysomnographic control, the patients underwent repeated 24-hour study sessions covering the entire clinical course of the disease. Hormones were assayed at 30-min intervals. Four healthy volunteers were used as controls. A sleep/wake cycle was always absent in fatal familial insomnia. Serum somatotropin and prolactin concentrations never exceeded the normal range of variation. The nocturnal elevation of somatotropin disappeared simultaneously with sleep loss, whereas a significant 24-hour component of variations in serum prolactin levels was present for months after total disruption of the sleep/wake cycle, with normally placed nocturnal acrophases. Complete obliteration of the 24-hour component was achieved for prolactin only in the advanced stages, through a progressive decrease in 24-hour amplitude of variation. Selective and progressive degeneration of the mediodorsal and anterior ventral nuclei of the thalamus causes an early obliteration of the 24-hour rhythm of somatotropin and a later disappearance of circadian prolactin rhythmicity. The persistence of a significant circadian rhythm for months after total disruption of the sleep/wake cycle indicates that prolactin rhythmicity is not exclusively sleep-entrained.

Original languageEnglish
Pages (from-to)731-737
Number of pages7
Issue number6
Publication statusPublished - 1995


  • Circadian rhythms
  • Clinical neuroendocrinology
  • Insomnia
  • Prolactin
  • Somatotropin
  • Thalamic diseases

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)


Dive into the research topics of 'Dissociated 24-Hour patterns of somatotropin and prolactin in fatal familial insomnia'. Together they form a unique fingerprint.

Cite this