Dissociation between syncytia formation and HIV spreading. Suppression of syncytia formation does not necessarily reflect inhibition of HIV infection

Giuseppe Pantaleo, Guido Poli, Luca Butini, Cecil Fox, Andrew I. Dayton, Anthony S. Fauci

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we have observed that a dissociation may occur in vitro between syncytia formation and HIV spreading. Efficient HIV spreading and virus replication occurred either in HIV-infected LFA-1+ lymphocytes treated with anti-LFA-1 mAb or in HIV-infected lymphocytes genetically deficient in LFA-1, despite the fact that syncytia formation was completely suppressed. Therefore, these results indicate that syncytia formation cannot be used as the sole parameter to evaluate the spread of HIV in vitro.

Original languageEnglish
Pages (from-to)1771-1774
Number of pages4
JournalEuropean Journal of Immunology
Volume21
Issue number7
Publication statusPublished - Jul 1991

ASJC Scopus subject areas

  • Immunology

Fingerprint

Dive into the research topics of 'Dissociation between syncytia formation and HIV spreading. Suppression of syncytia formation does not necessarily reflect inhibition of HIV infection'. Together they form a unique fingerprint.

Cite this