Dissociation induced by voluntary movement between two different components of the centro-parietal P40 SEP to tibial nerve stimulation

Massimiliano Valeriani, Domenico Restuccia, Vincenzo Di Lazzaro, Carmen Barba, Domenica Le Pera, Pietro Tonali

Research output: Contribution to journalArticlepeer-review

Abstract

Whether the two earliest cortical somatosensory evoked potentials (SEPs) to tibial nerve stimulation (N37 and P40) are generated by the same dipolar source or, instead, originate from different neuronal populations is still a debated problem. We recorded the early scalp SEPs to tibial nerve stimulation in 10 healthy subjects at rest and during voluntary movement of the stimulated foot. We found that the P40, which reached its highest amplitude on the vertex at rest, changed its topography during movement, since its amplitude was reduced much more in the central than in the parietal traces. These findings suggest that two different components contribute to the centro-parietal positivity at rest: (1) the P37 response, which is parietally distributed and is not modified by movement, and (2) the 'real' P40 SEP, which is focused on the vertex and is reduced in amplitude during voluntary movement. Since, also, the N37 response did not vary its amplitude under interference condition, it is possible that the N37 and P37 potentials are generated by the same dipolar source. Other later components, namely P50 and N50 were significantly reduced in amplitude during foot movement. Lastly, the subcortical P30 far-field remained unchanged and this suggests that the phenomenon of amplitude reduction during movement (i.e. gating) occurs above the cervicomedullary junction.

Original languageEnglish
Pages (from-to)190-198
Number of pages9
JournalElectroencephalography and Clinical Neurophysiology
Volume108
Issue number2
Publication statusPublished - 1998

Keywords

  • Gating
  • P40
  • Seps
  • Tibial nerve

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Dissociation induced by voluntary movement between two different components of the centro-parietal P40 SEP to tibial nerve stimulation'. Together they form a unique fingerprint.

Cite this