Distal hyperplastic polyps do not predict proximal adenomas: Results from a multicentric study of colorectal adenomas

S. Sciallero, M. Costantini, E. Bertinelli, G. Castiglione, P. Onofri, H. Aste, T. Casetti, P. Mantellini, L. Bucchi, R. Parri, L. Boni, L. Bonelli, B. Gatteschi, G. Lanzanova, P. Rinaldi, A. Giannini, C. Naldoni, P. Bruzzi

Research output: Contribution to journalArticle

Abstract

Background: The association between distal hyperplastic polyps and proximal adenomas is still a matter of debate. We investigated this association while taking into account patient characteristics. Methods: After exclusion of patients with inflammatory bowel diseases, familial adenomatous polyposis, or any cancer, 3088 eligible consecutive subjects aged 18 to 69 years underwent total colonoscopy in four gastro-enterology units. The odds ratios (OR) of having proximal adenomas according to patient characteristics (age, sex, medical center, year of endoscopy, reasons for referral, and distal findings) were estimated in univariate and multivariate analyses. Results: Patients with distal polyps of any type showed an adjusted OR of 2.5 (95% CI [1.9, 3.1] p <.001) of having proximal adenomas as compared with those without distal polyps. When distal adenomas and distal hyperplastic polyps were included in the multivariate model as independent factors, the presence of adenomas significantly increased the risk of proximal adenomas (OR = 2.8: 95% CI [2.2, 3.6] p <.001), whereas the presence of hyperplastic polyps did not (OR = 1.1: 95% CI [0.8, 1.5] p = .64). No association with number, size, or location of distal hyperplastic polyps was seen. Conclusions: Our data show that the presence of hyperplastic polyps should not be the sole indication for total colonoscopy because they are not associated with proximal adenomas when adjusting for patient characteristics and presence of distal adenomas.

Original languageEnglish
Pages (from-to)124-130
Number of pages7
JournalGastrointestinal Endoscopy
Volume46
Issue number2
DOIs
Publication statusPublished - 1997

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Polyps
Adenoma
Odds Ratio
Colonoscopy
Adenomatous Polyposis Coli
Inflammatory Bowel Diseases
Sex Characteristics
Endoscopy
Referral and Consultation
Multivariate Analysis
Neoplasms

ASJC Scopus subject areas

  • Gastroenterology

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Distal hyperplastic polyps do not predict proximal adenomas : Results from a multicentric study of colorectal adenomas. / Sciallero, S.; Costantini, M.; Bertinelli, E.; Castiglione, G.; Onofri, P.; Aste, H.; Casetti, T.; Mantellini, P.; Bucchi, L.; Parri, R.; Boni, L.; Bonelli, L.; Gatteschi, B.; Lanzanova, G.; Rinaldi, P.; Giannini, A.; Naldoni, C.; Bruzzi, P.

In: Gastrointestinal Endoscopy, Vol. 46, No. 2, 1997, p. 124-130.

Research output: Contribution to journalArticle

Sciallero, S, Costantini, M, Bertinelli, E, Castiglione, G, Onofri, P, Aste, H, Casetti, T, Mantellini, P, Bucchi, L, Parri, R, Boni, L, Bonelli, L, Gatteschi, B, Lanzanova, G, Rinaldi, P, Giannini, A, Naldoni, C & Bruzzi, P 1997, 'Distal hyperplastic polyps do not predict proximal adenomas: Results from a multicentric study of colorectal adenomas', Gastrointestinal Endoscopy, vol. 46, no. 2, pp. 124-130. https://doi.org/10.1016/S0016-5107(97)70059-2
Sciallero, S. ; Costantini, M. ; Bertinelli, E. ; Castiglione, G. ; Onofri, P. ; Aste, H. ; Casetti, T. ; Mantellini, P. ; Bucchi, L. ; Parri, R. ; Boni, L. ; Bonelli, L. ; Gatteschi, B. ; Lanzanova, G. ; Rinaldi, P. ; Giannini, A. ; Naldoni, C. ; Bruzzi, P. / Distal hyperplastic polyps do not predict proximal adenomas : Results from a multicentric study of colorectal adenomas. In: Gastrointestinal Endoscopy. 1997 ; Vol. 46, No. 2. pp. 124-130.
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abstract = "Background: The association between distal hyperplastic polyps and proximal adenomas is still a matter of debate. We investigated this association while taking into account patient characteristics. Methods: After exclusion of patients with inflammatory bowel diseases, familial adenomatous polyposis, or any cancer, 3088 eligible consecutive subjects aged 18 to 69 years underwent total colonoscopy in four gastro-enterology units. The odds ratios (OR) of having proximal adenomas according to patient characteristics (age, sex, medical center, year of endoscopy, reasons for referral, and distal findings) were estimated in univariate and multivariate analyses. Results: Patients with distal polyps of any type showed an adjusted OR of 2.5 (95{\%} CI [1.9, 3.1] p <.001) of having proximal adenomas as compared with those without distal polyps. When distal adenomas and distal hyperplastic polyps were included in the multivariate model as independent factors, the presence of adenomas significantly increased the risk of proximal adenomas (OR = 2.8: 95{\%} CI [2.2, 3.6] p <.001), whereas the presence of hyperplastic polyps did not (OR = 1.1: 95{\%} CI [0.8, 1.5] p = .64). No association with number, size, or location of distal hyperplastic polyps was seen. Conclusions: Our data show that the presence of hyperplastic polyps should not be the sole indication for total colonoscopy because they are not associated with proximal adenomas when adjusting for patient characteristics and presence of distal adenomas.",
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T1 - Distal hyperplastic polyps do not predict proximal adenomas

T2 - Results from a multicentric study of colorectal adenomas

AU - Sciallero, S.

AU - Costantini, M.

AU - Bertinelli, E.

AU - Castiglione, G.

AU - Onofri, P.

AU - Aste, H.

AU - Casetti, T.

AU - Mantellini, P.

AU - Bucchi, L.

AU - Parri, R.

AU - Boni, L.

AU - Bonelli, L.

AU - Gatteschi, B.

AU - Lanzanova, G.

AU - Rinaldi, P.

AU - Giannini, A.

AU - Naldoni, C.

AU - Bruzzi, P.

PY - 1997

Y1 - 1997

N2 - Background: The association between distal hyperplastic polyps and proximal adenomas is still a matter of debate. We investigated this association while taking into account patient characteristics. Methods: After exclusion of patients with inflammatory bowel diseases, familial adenomatous polyposis, or any cancer, 3088 eligible consecutive subjects aged 18 to 69 years underwent total colonoscopy in four gastro-enterology units. The odds ratios (OR) of having proximal adenomas according to patient characteristics (age, sex, medical center, year of endoscopy, reasons for referral, and distal findings) were estimated in univariate and multivariate analyses. Results: Patients with distal polyps of any type showed an adjusted OR of 2.5 (95% CI [1.9, 3.1] p <.001) of having proximal adenomas as compared with those without distal polyps. When distal adenomas and distal hyperplastic polyps were included in the multivariate model as independent factors, the presence of adenomas significantly increased the risk of proximal adenomas (OR = 2.8: 95% CI [2.2, 3.6] p <.001), whereas the presence of hyperplastic polyps did not (OR = 1.1: 95% CI [0.8, 1.5] p = .64). No association with number, size, or location of distal hyperplastic polyps was seen. Conclusions: Our data show that the presence of hyperplastic polyps should not be the sole indication for total colonoscopy because they are not associated with proximal adenomas when adjusting for patient characteristics and presence of distal adenomas.

AB - Background: The association between distal hyperplastic polyps and proximal adenomas is still a matter of debate. We investigated this association while taking into account patient characteristics. Methods: After exclusion of patients with inflammatory bowel diseases, familial adenomatous polyposis, or any cancer, 3088 eligible consecutive subjects aged 18 to 69 years underwent total colonoscopy in four gastro-enterology units. The odds ratios (OR) of having proximal adenomas according to patient characteristics (age, sex, medical center, year of endoscopy, reasons for referral, and distal findings) were estimated in univariate and multivariate analyses. Results: Patients with distal polyps of any type showed an adjusted OR of 2.5 (95% CI [1.9, 3.1] p <.001) of having proximal adenomas as compared with those without distal polyps. When distal adenomas and distal hyperplastic polyps were included in the multivariate model as independent factors, the presence of adenomas significantly increased the risk of proximal adenomas (OR = 2.8: 95% CI [2.2, 3.6] p <.001), whereas the presence of hyperplastic polyps did not (OR = 1.1: 95% CI [0.8, 1.5] p = .64). No association with number, size, or location of distal hyperplastic polyps was seen. Conclusions: Our data show that the presence of hyperplastic polyps should not be the sole indication for total colonoscopy because they are not associated with proximal adenomas when adjusting for patient characteristics and presence of distal adenomas.

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