Distinct alternative splicing patterns of mediator subunit genes during endothelial progenitor cell differentiation

Monica Rienzo, Amelia Casamassimi, Concetta Schiano, Vincenzo Grimaldi, Teresa Infante, Claudio Napoli

Research output: Contribution to journalArticlepeer-review

Abstract

Mediator (MED) is a fundamental component of the RNA polymerase II-mediated transcription machinery playing a pivotal role in the regulation of eukaryotic mRNA synthesis. Human MED complexes contain at least 30 distinct MED subunits. Our previous study, aimed to analyse MED complex during the pattern of endothelial progenitor cells (EPCs) differentiation, found an alternative transcript of MED30 subunit expressed only in circulating immature progenitor cells. Here, we report two novel transcripts of MED12 and MED19 subunits both generated by alternative splicing and displaying similar expression patterns, thereby indicating their involvement during endothelial cell differentiation.

Original languageEnglish
Pages (from-to)1828-1832
Number of pages5
JournalBiochimie
Volume94
Issue number8
DOIs
Publication statusPublished - Aug 2012

Keywords

  • Alternative splicing
  • CD133 positive cells
  • Endothelial progenitor cells
  • MED12
  • MED19
  • Mediator complex

ASJC Scopus subject areas

  • Biochemistry

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