Distinct modes of functional connectivity induced by movie-watching

Murat Demirtaş, Adrian Ponce-Alvarez, Matthieu Gilson, Patric Hagmann, Dante Mantini, Viviana Betti, Gian Luca Romani, Karl Friston, Maurizio Corbetta, Gustavo Deco

Research output: Contribution to journalArticlepeer-review

Abstract

A fundamental question in systems neuroscience is how endogenous neuronal activity self-organizes during particular brain states. Recent neuroimaging studies have demonstrated systematic relationships between resting-state and task-induced functional connectivity (FC). In particular, continuous task studies, such as movie watching, speak to alterations in coupling among cortical regions and enhanced fluctuations in FC compared to the resting-state. This suggests that FC may reflect systematic and large-scale reorganization of functionally integrated responses while subjects are watching movies. In this study, we characterized fluctuations in FC during resting-state and movie-watching conditions. We found that the FC patterns induced systematically by movie-watching can be explained with a single principal component. These condition-specific FC fluctuations overlapped with inter-subject synchronization patterns in occipital and temporal brain regions. However, unlike inter-subject synchronization, condition-specific FC patterns were characterized by increased correlations within frontal brain regions and reduced correlations between frontal-parietal brain regions. We investigated these condition-specific functional variations as a shorter time scale, using time-resolved FC. The time-resolved FC showed condition-specificity over time; notably when subjects watched both the same and different movies. To explain self-organisation of global FC through the alterations in local dynamics, we used a large-scale computational model. We found that condition-specific reorganization of FC could be explained by local changes that engendered changes in FC among higher-order association regions, mainly in frontal and parietal cortices.

Original languageEnglish
Pages (from-to)335-348
Number of pages14
JournalNeuroImage
Volume184
DOIs
Publication statusE-pub ahead of print - Sep 17 2018

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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