Distinct neural substrates for semantic knowledge and naming in the temporoparietal network

Benno Gesierich, Jorge Jovicich, Marianna Riello, Michela Adriani, Alessia Monti, Valentina Brentari, Simon D. Robinson, Stephen M. Wilson, Scott L. Fairhall, Maria Luisa Gorno-Tempini

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Patients with anterior temporal lobe (ATL) lesions show semantic and lexical retrieval deficits, and the differential role of this area in the 2 processes is debated. Functional neuroimaging in healthy individuals has not clarified the matter because semantic and lexical processes usually occur simultaneously and automatically. Furthermore, the ATL is a region challenging for functional magnetic resonance imaging (fMRI) due to susceptibility artifacts, especially at high fields. In this study, we established an optimized ATL-sensitive fMRI acquisition protocol at 4 T and applied an event-related paradigm to study the identification (i.e., association of semantic biographical information) of celebrities, with and without the ability to retrieve their proper names. While semantic processing reliably activated the ATL, only more posterior areas in the left temporal and temporal-parietal junction were significantly modulated by covert lexical retrieval. These results suggest that within a temporoparietal network, the ATL is relatively more important for semantic processing, and posterior language regions are relatively more important for lexical retrieval.

Original languageEnglish
Pages (from-to)2217-2226
Number of pages10
JournalCerebral Cortex
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Temporal Lobe
Semantics
Magnetic Resonance Imaging
Functional Neuroimaging
Aptitude
Artifacts
Names
Language

Keywords

  • EPI optimization
  • famous faces
  • lexical retrieval
  • MRI
  • susceptibility artifacts

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Gesierich, B., Jovicich, J., Riello, M., Adriani, M., Monti, A., Brentari, V., ... Gorno-Tempini, M. L. (2012). Distinct neural substrates for semantic knowledge and naming in the temporoparietal network. Cerebral Cortex, 22(10), 2217-2226. https://doi.org/10.1093/cercor/bhr286

Distinct neural substrates for semantic knowledge and naming in the temporoparietal network. / Gesierich, Benno; Jovicich, Jorge; Riello, Marianna; Adriani, Michela; Monti, Alessia; Brentari, Valentina; Robinson, Simon D.; Wilson, Stephen M.; Fairhall, Scott L.; Gorno-Tempini, Maria Luisa.

In: Cerebral Cortex, Vol. 22, No. 10, 10.2012, p. 2217-2226.

Research output: Contribution to journalArticle

Gesierich, B, Jovicich, J, Riello, M, Adriani, M, Monti, A, Brentari, V, Robinson, SD, Wilson, SM, Fairhall, SL & Gorno-Tempini, ML 2012, 'Distinct neural substrates for semantic knowledge and naming in the temporoparietal network', Cerebral Cortex, vol. 22, no. 10, pp. 2217-2226. https://doi.org/10.1093/cercor/bhr286
Gesierich B, Jovicich J, Riello M, Adriani M, Monti A, Brentari V et al. Distinct neural substrates for semantic knowledge and naming in the temporoparietal network. Cerebral Cortex. 2012 Oct;22(10):2217-2226. https://doi.org/10.1093/cercor/bhr286
Gesierich, Benno ; Jovicich, Jorge ; Riello, Marianna ; Adriani, Michela ; Monti, Alessia ; Brentari, Valentina ; Robinson, Simon D. ; Wilson, Stephen M. ; Fairhall, Scott L. ; Gorno-Tempini, Maria Luisa. / Distinct neural substrates for semantic knowledge and naming in the temporoparietal network. In: Cerebral Cortex. 2012 ; Vol. 22, No. 10. pp. 2217-2226.
@article{db59e3b48196465fa74caae54564a442,
title = "Distinct neural substrates for semantic knowledge and naming in the temporoparietal network",
abstract = "Patients with anterior temporal lobe (ATL) lesions show semantic and lexical retrieval deficits, and the differential role of this area in the 2 processes is debated. Functional neuroimaging in healthy individuals has not clarified the matter because semantic and lexical processes usually occur simultaneously and automatically. Furthermore, the ATL is a region challenging for functional magnetic resonance imaging (fMRI) due to susceptibility artifacts, especially at high fields. In this study, we established an optimized ATL-sensitive fMRI acquisition protocol at 4 T and applied an event-related paradigm to study the identification (i.e., association of semantic biographical information) of celebrities, with and without the ability to retrieve their proper names. While semantic processing reliably activated the ATL, only more posterior areas in the left temporal and temporal-parietal junction were significantly modulated by covert lexical retrieval. These results suggest that within a temporoparietal network, the ATL is relatively more important for semantic processing, and posterior language regions are relatively more important for lexical retrieval.",
keywords = "EPI optimization, famous faces, lexical retrieval, MRI, susceptibility artifacts",
author = "Benno Gesierich and Jorge Jovicich and Marianna Riello and Michela Adriani and Alessia Monti and Valentina Brentari and Robinson, {Simon D.} and Wilson, {Stephen M.} and Fairhall, {Scott L.} and Gorno-Tempini, {Maria Luisa}",
year = "2012",
month = "10",
doi = "10.1093/cercor/bhr286",
language = "English",
volume = "22",
pages = "2217--2226",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Distinct neural substrates for semantic knowledge and naming in the temporoparietal network

AU - Gesierich, Benno

AU - Jovicich, Jorge

AU - Riello, Marianna

AU - Adriani, Michela

AU - Monti, Alessia

AU - Brentari, Valentina

AU - Robinson, Simon D.

AU - Wilson, Stephen M.

AU - Fairhall, Scott L.

AU - Gorno-Tempini, Maria Luisa

PY - 2012/10

Y1 - 2012/10

N2 - Patients with anterior temporal lobe (ATL) lesions show semantic and lexical retrieval deficits, and the differential role of this area in the 2 processes is debated. Functional neuroimaging in healthy individuals has not clarified the matter because semantic and lexical processes usually occur simultaneously and automatically. Furthermore, the ATL is a region challenging for functional magnetic resonance imaging (fMRI) due to susceptibility artifacts, especially at high fields. In this study, we established an optimized ATL-sensitive fMRI acquisition protocol at 4 T and applied an event-related paradigm to study the identification (i.e., association of semantic biographical information) of celebrities, with and without the ability to retrieve their proper names. While semantic processing reliably activated the ATL, only more posterior areas in the left temporal and temporal-parietal junction were significantly modulated by covert lexical retrieval. These results suggest that within a temporoparietal network, the ATL is relatively more important for semantic processing, and posterior language regions are relatively more important for lexical retrieval.

AB - Patients with anterior temporal lobe (ATL) lesions show semantic and lexical retrieval deficits, and the differential role of this area in the 2 processes is debated. Functional neuroimaging in healthy individuals has not clarified the matter because semantic and lexical processes usually occur simultaneously and automatically. Furthermore, the ATL is a region challenging for functional magnetic resonance imaging (fMRI) due to susceptibility artifacts, especially at high fields. In this study, we established an optimized ATL-sensitive fMRI acquisition protocol at 4 T and applied an event-related paradigm to study the identification (i.e., association of semantic biographical information) of celebrities, with and without the ability to retrieve their proper names. While semantic processing reliably activated the ATL, only more posterior areas in the left temporal and temporal-parietal junction were significantly modulated by covert lexical retrieval. These results suggest that within a temporoparietal network, the ATL is relatively more important for semantic processing, and posterior language regions are relatively more important for lexical retrieval.

KW - EPI optimization

KW - famous faces

KW - lexical retrieval

KW - MRI

KW - susceptibility artifacts

UR - http://www.scopus.com/inward/record.url?scp=84866104665&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866104665&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhr286

DO - 10.1093/cercor/bhr286

M3 - Article

VL - 22

SP - 2217

EP - 2226

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 10

ER -