Abstract
Patients with anterior temporal lobe (ATL) lesions show semantic and lexical retrieval deficits, and the differential role of this area in the 2 processes is debated. Functional neuroimaging in healthy individuals has not clarified the matter because semantic and lexical processes usually occur simultaneously and automatically. Furthermore, the ATL is a region challenging for functional magnetic resonance imaging (fMRI) due to susceptibility artifacts, especially at high fields. In this study, we established an optimized ATL-sensitive fMRI acquisition protocol at 4 T and applied an event-related paradigm to study the identification (i.e., association of semantic biographical information) of celebrities, with and without the ability to retrieve their proper names. While semantic processing reliably activated the ATL, only more posterior areas in the left temporal and temporal-parietal junction were significantly modulated by covert lexical retrieval. These results suggest that within a temporoparietal network, the ATL is relatively more important for semantic processing, and posterior language regions are relatively more important for lexical retrieval.
| Original language | English |
|---|---|
| Pages (from-to) | 2217-2226 |
| Number of pages | 10 |
| Journal | Cerebral Cortex |
| Volume | 22 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2012 |
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Keywords
- EPI optimization
- famous faces
- lexical retrieval
- MRI
- susceptibility artifacts
ASJC Scopus subject areas
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience
Cite this
Distinct neural substrates for semantic knowledge and naming in the temporoparietal network. / Gesierich, Benno; Jovicich, Jorge; Riello, Marianna; Adriani, Michela; Monti, Alessia; Brentari, Valentina; Robinson, Simon D.; Wilson, Stephen M.; Fairhall, Scott L.; Gorno-Tempini, Maria Luisa.
In: Cerebral Cortex, Vol. 22, No. 10, 10.2012, p. 2217-2226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distinct neural substrates for semantic knowledge and naming in the temporoparietal network
AU - Gesierich, Benno
AU - Jovicich, Jorge
AU - Riello, Marianna
AU - Adriani, Michela
AU - Monti, Alessia
AU - Brentari, Valentina
AU - Robinson, Simon D.
AU - Wilson, Stephen M.
AU - Fairhall, Scott L.
AU - Gorno-Tempini, Maria Luisa
PY - 2012/10
Y1 - 2012/10
N2 - Patients with anterior temporal lobe (ATL) lesions show semantic and lexical retrieval deficits, and the differential role of this area in the 2 processes is debated. Functional neuroimaging in healthy individuals has not clarified the matter because semantic and lexical processes usually occur simultaneously and automatically. Furthermore, the ATL is a region challenging for functional magnetic resonance imaging (fMRI) due to susceptibility artifacts, especially at high fields. In this study, we established an optimized ATL-sensitive fMRI acquisition protocol at 4 T and applied an event-related paradigm to study the identification (i.e., association of semantic biographical information) of celebrities, with and without the ability to retrieve their proper names. While semantic processing reliably activated the ATL, only more posterior areas in the left temporal and temporal-parietal junction were significantly modulated by covert lexical retrieval. These results suggest that within a temporoparietal network, the ATL is relatively more important for semantic processing, and posterior language regions are relatively more important for lexical retrieval.
AB - Patients with anterior temporal lobe (ATL) lesions show semantic and lexical retrieval deficits, and the differential role of this area in the 2 processes is debated. Functional neuroimaging in healthy individuals has not clarified the matter because semantic and lexical processes usually occur simultaneously and automatically. Furthermore, the ATL is a region challenging for functional magnetic resonance imaging (fMRI) due to susceptibility artifacts, especially at high fields. In this study, we established an optimized ATL-sensitive fMRI acquisition protocol at 4 T and applied an event-related paradigm to study the identification (i.e., association of semantic biographical information) of celebrities, with and without the ability to retrieve their proper names. While semantic processing reliably activated the ATL, only more posterior areas in the left temporal and temporal-parietal junction were significantly modulated by covert lexical retrieval. These results suggest that within a temporoparietal network, the ATL is relatively more important for semantic processing, and posterior language regions are relatively more important for lexical retrieval.
KW - EPI optimization
KW - famous faces
KW - lexical retrieval
KW - MRI
KW - susceptibility artifacts
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U2 - 10.1093/cercor/bhr286
DO - 10.1093/cercor/bhr286
M3 - Article
VL - 22
SP - 2217
EP - 2226
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 10
ER -