Distinct olfactory cross-modal effects on the human motor system

Simone Rossi, Alberto De Capua, Patrizio Pasqualetti, Monica Ulivelli, Luciano Fadiga, Vincenzo Falzarano, Sabina Bartalini, Stefano Passero, Daniele Nuti, Paolo M. Rossini

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Converging evidence indicates that action observation and action-related sounds activate cross-modally the Human motor system. Since olfaction, the most ancestral sense, may have behavioural consequences on human activities, we causally investigated by transcranial magnetic stimulation (TMS) whether food odour could additionally facilitate the human motor system during the observation of grasping objects with alimentary valence, and the degree of specificity of these effects. Methodology/Principal Findings: In a repeated measure block design, carried out on 24 healthy individuals participating to three different experiments we show that sniffing alimentary odorants immediately increases the motor potentials evoked in hand muscles by TMS of the motor cortex. This effect was odorant-specific and was absent when subjects were presented with odorants including a potentially noxious trigeminal component. The smell-induced corticospinal facilitation of hand muscles during observation of grasping was an additive effect which superimposed to that induced by the mere observation bf grasping actions for food or non-food objects. The odour-induced motor facilitation took place only in case of congruence between the sniffed odour and the observed grasped food, and specifically involved the muscle acting as prime mover for hand/fingers shaping in the observed action. Conclusions/Significance: Complex olfactory cross-modal effects on the human corticospinal system are physiologically demonstrable. They are odorant-specific and, depending on the experimental context, muscle- and action-specific as well. This finding implies potential new diagnostic and rehabilitative applications.

Original languageEnglish
Article numbere1702
JournalPLoS One
Volume3
Issue number2
DOIs
Publication statusPublished - Feb 27 2008

Fingerprint

odor compounds
Muscle
Odors
muscles
hands
odors
smell
Observation
Muscles
Transcranial Magnetic Stimulation
Hand
Smell
evoked potentials
Food
additive effect
Bioelectric potentials
Motor Evoked Potentials
Motor Cortex
Odorants
Acoustic waves

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Rossi, S., De Capua, A., Pasqualetti, P., Ulivelli, M., Fadiga, L., Falzarano, V., ... Rossini, P. M. (2008). Distinct olfactory cross-modal effects on the human motor system. PLoS One, 3(2), [e1702]. https://doi.org/10.1371/journal.pone.0001702

Distinct olfactory cross-modal effects on the human motor system. / Rossi, Simone; De Capua, Alberto; Pasqualetti, Patrizio; Ulivelli, Monica; Fadiga, Luciano; Falzarano, Vincenzo; Bartalini, Sabina; Passero, Stefano; Nuti, Daniele; Rossini, Paolo M.

In: PLoS One, Vol. 3, No. 2, e1702, 27.02.2008.

Research output: Contribution to journalArticle

Rossi, S, De Capua, A, Pasqualetti, P, Ulivelli, M, Fadiga, L, Falzarano, V, Bartalini, S, Passero, S, Nuti, D & Rossini, PM 2008, 'Distinct olfactory cross-modal effects on the human motor system', PLoS One, vol. 3, no. 2, e1702. https://doi.org/10.1371/journal.pone.0001702
Rossi S, De Capua A, Pasqualetti P, Ulivelli M, Fadiga L, Falzarano V et al. Distinct olfactory cross-modal effects on the human motor system. PLoS One. 2008 Feb 27;3(2). e1702. https://doi.org/10.1371/journal.pone.0001702
Rossi, Simone ; De Capua, Alberto ; Pasqualetti, Patrizio ; Ulivelli, Monica ; Fadiga, Luciano ; Falzarano, Vincenzo ; Bartalini, Sabina ; Passero, Stefano ; Nuti, Daniele ; Rossini, Paolo M. / Distinct olfactory cross-modal effects on the human motor system. In: PLoS One. 2008 ; Vol. 3, No. 2.
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