Distinct pattern of HSP72 and monomeric laminin receptor expression in human lung cancers infiltrated by γ/δ t T. lymphocytes

M. Ferrarini, S. M. Pupa, M. R. Zocchi, C. Rugarli, S. Menard

Research output: Contribution to journalArticle

Abstract

We have previously demonstrated that γ/δ T lymphocytes may participate in the host immune response against lung adenocarcinomas. Here we show that, in about one-fourth of human lung cancers, γ/δ T cells represented a significant proportion of freshly isolated tumor-infiltrating lymphocytes. Moreover, these cells selectively expand in vitro upon culture in the presence of IL-2, thus suggesting a prior activation in vivo. Finally, when we evaluated the expression of heat shock proteins and of a panel of tumor-associated antigens in lung cancers infiltrated by γ/δ vs. α/β T cells, we found that the former displayed a distinct antigenic pattern, characterized by over-expression of HSP72 and of the 67-kDa high-affinity laminin-receptor, which might account for γ/δ T-cell recognition.

Original languageEnglish
Pages (from-to)486-490
Number of pages5
JournalInternational Journal of Cancer
Volume57
Issue number4
DOIs
Publication statusPublished - 1994

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this