Distinct patterns of HIV-specific memory T lymphocytes in HIV-exposed uninfected individuals and in HIV-infected patients

Monica Schenal, Sergio Lo Caputo, Francesca Fasano, Francesca Vichi, Marina Saresella, Piera Pierotti, Maria Luisa Villa, Francesco Mazzotta, Daria Trabattoni, Mario Clerici

Research output: Contribution to journalArticle

Abstract

Background: Repeated exposure to HIV is not always associated with infection and multiple cohorts of HIV-exposed but seronegative individuals (ESN) have been described. HIV-specific CD4 and CD8 T lymphocytes are detected both in HIV patients and in ESN; we verified whether different patterns of HIV-specific memory T lymphocytes would be detected in individuals in whom exposure to HIV results or does not result in infection. Methods: Gag-specific T cells were analysed in 15 ESN, 14 HIV patients, and 15 healthy controls using extensive flow cytometry analysis. Results: Data confirmed that gag-specific T lymphocytes are present in ESN. Gag-specific T cells mainly secrete interleukin-2 in ESN and interferon-γ in HIV patients. In addition the CD4/CD8 and the memory/naive ratios are altered, central memory (45RA-/CCR7+) CD4 and CD8 T lymphocytes are more abundant, and terminally differentiated (45RA+/ CCR7- and 27-728-) CD8 T lymphocytes are augmented in ESN individuals. Conclusions: Exposure to HIV occurs in high risk seronegative individuals; the observation that naive cells and CM are skewed in ESN indicate that this exposure is robust enough to modulate the CM/EM ratio. The increase in late effectors and in natural killer cells seen in ESN suggests a role for these cells in preventing actual infection.

Original languageEnglish
Pages (from-to)653-661
Number of pages9
JournalAIDS (London, England)
Volume19
Issue number7
Publication statusPublished - Apr 29 2005

Keywords

  • HIV
  • Immunology
  • Memory/naive T lymphocytes
  • Resistance to infection
  • Vaccines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Schenal, M., Lo Caputo, S., Fasano, F., Vichi, F., Saresella, M., Pierotti, P., Villa, M. L., Mazzotta, F., Trabattoni, D., & Clerici, M. (2005). Distinct patterns of HIV-specific memory T lymphocytes in HIV-exposed uninfected individuals and in HIV-infected patients. AIDS (London, England), 19(7), 653-661.