Distinct renal injury in early atherosclerosis and renovascular disease

Alejandro R. Chade, Martin Rodriguez-Porcel, Joseph P. Grande, James D. Krier, Amir Lerman, J. Carlos Romero, Claudio Napoli, Lilach O. Lerman

Research output: Contribution to journalArticle

Abstract

Background - Atherosclerotic renovascular disease may augment deterioration of renal function and ischemic nephropathy compared with other causes of renal artery stenosis (RAS), but the underlying mechanisms remain unclear. This study was designed to test the hypothesis that concurrent early atherosclerosis and hypoperfusion might have greater early deleterious effects on the function and structure of the stenotic kidney. Methods and Results - Regional renal hemodynamics and function at baseline and during vasoactive challenge (acetylcholine or sodium nitroprusside) were quantified in vivo in pigs by electron-beam computed tomography after a 12-week normal (n=7) or hypercholesterolemic (HC, n=7) diet, RAS (n=6), or concurrent HC and a similar degree of RAS (HC+RAS, n=7). Flash-frozen renal tissue was studied ex vivo. Basal cortical perfusion and single-kidney glomerular filtration rate (GFR) were decreased similarly in the stenotic RAS and HC+RAS kidneys, but tubular fluid reabsorption was markedly impaired only in HC+RAS. Perfusion responses to challenge were similarly blunted in the experimental groups. Stimulated GFR increased in normal, HC, and RAS (38.3±3.6%, 36.4±7.6%, and 60.4±9.3%, respectively, P

Original languageEnglish
Pages (from-to)1165-1171
Number of pages7
JournalCirculation
Volume106
Issue number9
DOIs
Publication statusPublished - Aug 27 2002

Keywords

  • Atherosclerosis
  • Kidney
  • Regional blood flow

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Chade, A. R., Rodriguez-Porcel, M., Grande, J. P., Krier, J. D., Lerman, A., Romero, J. C., Napoli, C., & Lerman, L. O. (2002). Distinct renal injury in early atherosclerosis and renovascular disease. Circulation, 106(9), 1165-1171. https://doi.org/10.1161/01.CIR.0000027105.02327.48