Distinct roles of cortical and pallidal β and γ frequencies in hemiparkinsonian and dyskinetic rats

Agnese Salvadè, Vincenza D'Angelo, Giuseppe Di Giovanni, Gerd Tinkhauser, Giuseppe Sancesario, Claudio Städler, Jens C. Möller, Alessandro Stefani, Alain Kaelin-Lang, Salvatore Galati

Research output: Contribution to journalArticlepeer-review

Abstract

Enhanced β band (βB) activity, which is suppressed by levodopa (LD) treatment, has been demonstrated within the basal ganglia (BG) of Parkinson's disease (PD) patients. However, some data suggest that Parkinsonian symptoms are not directly related to this brain frequency and therefore, its causative role remains questionable. A less explored phenomenon is the link between the γ band (γB) and PD phenomenology. Here, we monitored the development of the oscillatory activity during chronic LD depletion and LD treatment in Parkinsonian and levodopa-induced dyskinesia (LID) in rats. We found a significant and bilateral power increase in the high βB frequencies (20-30. Hz) within the first 10. days after 6-hydroxydopamine (6-OHDA) lesion, which was in accordance with a significant depletion of dopaminergic fibers in the striatum. We also observed a clear-cut γB increase during LD treatment. The development of LID was characterized by a slight increase in the cumulative power of βB accompanied by a large augmentation in the γB frequency (60-80. Hz). This latter effect reached a plateau in the frontal cortex bilaterally and the left globus pallidus after the second week of LD treatment. Our data suggest that the βB parallels the emergence of Parkinsonian signs and can be taken as a predictive sign of DA depletion, matching TH-staining reduction. On the other hand, the γB is strictly correlated to the development of LID. LD treatment had an opposite effect on βB and γB, respectively.

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalExperimental Neurology
Volume275
DOIs
Publication statusE-pub ahead of print - Nov 10 2015

Keywords

  • Beta band oscillation
  • Local field potentials
  • Parkinson's disease
  • Rat animal model
  • Recordings in freely moving animals

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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