Distinct roles of diverse nuclear factor-κB complexes in neuropathological mechanisms

Marina Pizzi, PierFranco Spano

Research output: Contribution to journalArticlepeer-review

Abstract

The nuclear transcription factors κB (NF-κB) function as key regulators of physiological processes in the central nervous system. Aberrant regulation of NF-κB can underlie neurological disorders associated with neurodegeneration. A large number of studies have reported a dual role of NF-κB in regulating neuron survival in pathological conditions. A recent progress in understanding the mechanisms responsible for opposite effects elicited by NF-κB in brain dysfunctions arises from the identification of diverse NF-κB complexes specifically involved in the mechanism of neuronal cell death or cell survival. We here discuss the latest findings and consider the therapeutic potential of targeting distinct NF-κB complexes for the treatment of neurodegenerative disorders and memory dysfunctions.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalEuropean Journal of Pharmacology
Volume545
Issue number1
DOIs
Publication statusPublished - Sep 1 2006

Keywords

  • Amyloid beta
  • c-Rel
  • Cell death
  • Neurodegeneration
  • Nuclear factor-kappaB
  • p65

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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