Abstract
The nuclear transcription factors κB (NF-κB) function as key regulators of physiological processes in the central nervous system. Aberrant regulation of NF-κB can underlie neurological disorders associated with neurodegeneration. A large number of studies have reported a dual role of NF-κB in regulating neuron survival in pathological conditions. A recent progress in understanding the mechanisms responsible for opposite effects elicited by NF-κB in brain dysfunctions arises from the identification of diverse NF-κB complexes specifically involved in the mechanism of neuronal cell death or cell survival. We here discuss the latest findings and consider the therapeutic potential of targeting distinct NF-κB complexes for the treatment of neurodegenerative disorders and memory dysfunctions.
Original language | English |
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Pages (from-to) | 22-28 |
Number of pages | 7 |
Journal | European Journal of Pharmacology |
Volume | 545 |
Issue number | 1 |
DOIs | |
Publication status | Published - Sep 1 2006 |
Keywords
- Amyloid beta
- c-Rel
- Cell death
- Neurodegeneration
- Nuclear factor-kappaB
- p65
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology