Distinction between patients with non-erosive reflux disease and functional heartburn

Maria Giacchino, Vincenzo Savarino, Edoardo Savarino

Research output: Contribution to journalArticle

Abstract

Non-erosive reflux disease (NERD) and functional heartburn (FH) are two different clinical entities and the clear distinction between the two forms is actually possible thanks to the use of impedance-pH monitoring. NERD is the more common manifestation of gastro-esophageal reflux disease (GERD), one of the most widespread chronic gastrointestinal disorders in Western countries. The absence of visible lesions on endoscopy and the presence of troublesome reflux-associated (to acid, weakly acidic or non-acid reflux) symptoms are the two key factors for the definition of NERD. FH is an exclusive diagnosis and is defined by the Rome III criteria as a burning retrosternal discomfort, excluding GERD and esophageal motility disorders as a cause of the symptom. FH does not have any type of reflux underlying symptoms and psychological factors seem to be more expressed in FH patients than in patients with reflux-provoked disturbances. The aim of our review is to report the state-of-the-art knowledge about NERD and FH, to clarify their features and differences and to stimulate new research in this field.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalAnnals of Gastroenterology
Volume26
Issue number4
Publication statusPublished - 2013

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Heartburn
Esophageal Diseases
Gastroesophageal Reflux
Esophageal Motility Disorders
Electric Impedance
Endoscopy
Psychology
Acids
Research

Keywords

  • Esophageal impedance-pH monitoring
  • Functional heartburn
  • Gastro-esophageal reflux disease
  • Non-erosive reflux disease
  • PPI

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Distinction between patients with non-erosive reflux disease and functional heartburn. / Giacchino, Maria; Savarino, Vincenzo; Savarino, Edoardo.

In: Annals of Gastroenterology, Vol. 26, No. 4, 2013, p. 283-289.

Research output: Contribution to journalArticle

Giacchino, M, Savarino, V & Savarino, E 2013, 'Distinction between patients with non-erosive reflux disease and functional heartburn', Annals of Gastroenterology, vol. 26, no. 4, pp. 283-289.
Giacchino, Maria ; Savarino, Vincenzo ; Savarino, Edoardo. / Distinction between patients with non-erosive reflux disease and functional heartburn. In: Annals of Gastroenterology. 2013 ; Vol. 26, No. 4. pp. 283-289.
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