Distinctive clinical and histological features of Waldenström's macroglobulinemia and splenic marginal zone lymphoma

Luca Arcaini, Marzia Varettoni, Emanuela Boveri, Ester Orlandi, Sara Rattotti, Silvia Zibellini, Michele Merli, Marco Lucioni, Silvia Rizzi, Manuel Gotti, Lucia Morello, Cristiana Pascutto, Marco Paulli

Research output: Contribution to journalArticlepeer-review

Abstract

We studied 122 patients with Waldenström's macroglobulinemia (WM) and 98 with splenic marginal zone lymphoma (SMZL); 29 SMZL patients (30%) had a serum MC (IgM in 17 patients). SMZL differed from WM for female prevalence, abdominal and superficial adenopathy, spleen and liver involvement, positive HCV. The median MC level was 2.0 g/dL in WM and 0.95 g/dL in SMZL (P <.001). On BM histology, SMZL was characterized by sinusoidal infiltration (70% of cases) and by a more frequent nodular pattern (P <.01) while WM had a higher incidence of interstitial BM localization. After a median follow-up of 5.3 years, median OS was not reached for SMZL and was 12 years for WM (P = .23; 14 years for asymptomatic WM, 8 years for symptomatic WM). In conclusion, despite similar outcomes of these 2 entities, SMZL appears as a disease with distinct clinical features and BM histology and a peculiar association with HCV infection.

Original languageEnglish
Pages (from-to)103-105
Number of pages3
JournalClinical Lymphoma, Myeloma and Leukemia
Volume11
Issue number1
DOIs
Publication statusPublished - Feb 1 2011

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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