TY - JOUR
T1 - Distinctive clinical and histological features of Waldenström's macroglobulinemia and splenic marginal zone lymphoma
AU - Arcaini, Luca
AU - Varettoni, Marzia
AU - Boveri, Emanuela
AU - Orlandi, Ester
AU - Rattotti, Sara
AU - Zibellini, Silvia
AU - Merli, Michele
AU - Lucioni, Marco
AU - Rizzi, Silvia
AU - Gotti, Manuel
AU - Morello, Lucia
AU - Pascutto, Cristiana
AU - Paulli, Marco
PY - 2011/2/1
Y1 - 2011/2/1
N2 - We studied 122 patients with Waldenström's macroglobulinemia (WM) and 98 with splenic marginal zone lymphoma (SMZL); 29 SMZL patients (30%) had a serum MC (IgM in 17 patients). SMZL differed from WM for female prevalence, abdominal and superficial adenopathy, spleen and liver involvement, positive HCV. The median MC level was 2.0 g/dL in WM and 0.95 g/dL in SMZL (P <.001). On BM histology, SMZL was characterized by sinusoidal infiltration (70% of cases) and by a more frequent nodular pattern (P <.01) while WM had a higher incidence of interstitial BM localization. After a median follow-up of 5.3 years, median OS was not reached for SMZL and was 12 years for WM (P = .23; 14 years for asymptomatic WM, 8 years for symptomatic WM). In conclusion, despite similar outcomes of these 2 entities, SMZL appears as a disease with distinct clinical features and BM histology and a peculiar association with HCV infection.
AB - We studied 122 patients with Waldenström's macroglobulinemia (WM) and 98 with splenic marginal zone lymphoma (SMZL); 29 SMZL patients (30%) had a serum MC (IgM in 17 patients). SMZL differed from WM for female prevalence, abdominal and superficial adenopathy, spleen and liver involvement, positive HCV. The median MC level was 2.0 g/dL in WM and 0.95 g/dL in SMZL (P <.001). On BM histology, SMZL was characterized by sinusoidal infiltration (70% of cases) and by a more frequent nodular pattern (P <.01) while WM had a higher incidence of interstitial BM localization. After a median follow-up of 5.3 years, median OS was not reached for SMZL and was 12 years for WM (P = .23; 14 years for asymptomatic WM, 8 years for symptomatic WM). In conclusion, despite similar outcomes of these 2 entities, SMZL appears as a disease with distinct clinical features and BM histology and a peculiar association with HCV infection.
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U2 - 10.3816/CLML.2011.n.020
DO - 10.3816/CLML.2011.n.020
M3 - Article
C2 - 21454204
AN - SCOPUS:79953675087
VL - 11
SP - 103
EP - 105
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
SN - 2152-2669
IS - 1
ER -