Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: Analysis of 156 patients from northern Italy

Carlo Visco, L. Arcaini, E. Brusamolino, S. Burcheri, A. Ambrosetti, M. Merli, E. Bonoldi, M. Chilosi, A. Viglio, M. Lazzarino, G. Pizzolo, F. Rodeghiero

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) has been correlated to hepatitis C virus (HCV) infection in few series, but characteristics and outcome of these patients remain undefined. Patients and methods: We analyzed 156 previously untreated consecutive HCV-positive patients with DLBCL observed between 1994 and 2004 in three major institutions from northern Italy. Results: Median age at presentation was 63 years and 8% of patients had DLBCL transformed from low-grade lymphomas. Spleen was the most frequently involved extranodal site, followed by liver and stomach. Treatment was delivered with cure-intent in 132 patients, while the remaining 24 patients received monochemotherapy or radiotherapy alone due to old age or seriously impaired hepatic function. Only five patients (4%) had to discontinue chemotherapy due to severe liver function impairment. The addition of rituximab did not seem to affect patients' tolerance to treatment. Five-year overall survival of the entire cohort was 72%, while 5-year progression-free survival (PFS) of the 132 patients treated with cure-intent was 51%. Hepatitis B virus co-infection, advanced Ann Arbor stage and nodal origin of the tumor resulted the strongest adverse prognostic factors. Conclusions: Patients with HCV-positive DLBCL share distinctive clinical features. Future studies should prospectively evaluate the association between HCV and aggressive lymphomas.

Original languageEnglish
Pages (from-to)1434-1440
Number of pages7
JournalAnnals of Oncology
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Diffuse large B-cell lymphoma
  • HBV
  • HCV
  • Hepatitis
  • Spleen

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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