Distinctive patterns of cortical excitability to transcranial magnetic stimulation in obstructive sleep apnea syndrome, restless legs syndrome, insomnia, and sleep deprivation

Giuseppe Lanza, Mariagiovanna Cantone, Bartolo Lanuzza, Manuela Pennisi, Rita Bella, Giovanni Pennisi, Raffaele Ferri

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Altered responses to transcranial magnetic stimulation (TMS) in obstructive sleep apnea syndrome (OSAS), restless legs syndrome (RLS), insomnia, and sleep-deprived healthy subjects have been reported. We have reviewed the relevant literature in order to identify eventual distinctive electrocortical profiles based on single and paired-pulse TMS, sensorimotor modulation, plasticity-related and repetitive TMS measures. Although obtained from heterogeneous studies, the detected changes might be the result of the different pathophysiological substrates underlying OSAS, RLS, insomnia and sleep deprivation rather than reflect the general effect of non-specific sleep loss and instability. OSAS tends to exhibit an increased motor cortex inhibition, which is reduced in RLS; intracortical excitability seems to be in favor of an "activating" profile in chronic insomnia and in sleep-deprived healthy individuals. Abnormal plasticity-related TMS phenomena have been demonstrated in OSAS and RLS. This review provides a perspective of TMS techniques by further understanding the role of neurotransmission pathways and plastic remodeling of neuronal networks involved in common sleep disorders. TMS might be considered a valuable tool in the assessment of sleep disorders, the evaluation of the effect of therapy and the design of non-pharmacological approaches.

Original languageEnglish
Pages (from-to)39-50
Number of pages12
JournalSleep Medicine Reviews
Volume19
DOIs
Publication statusPublished - Feb 1 2015

Fingerprint

Restless Legs Syndrome
Sleep Deprivation
Transcranial Magnetic Stimulation
Sleep Initiation and Maintenance Disorders
Obstructive Sleep Apnea
Sleep
Magnetic Phenomena
Neuronal Plasticity
Motor Cortex
Cortical Excitability
Synaptic Transmission
Plastics
Healthy Volunteers

Keywords

  • Cortical excitability
  • Neuronal plasticity
  • Neurotransmission
  • Sleep disorders
  • Sleep fragmentation

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Pulmonary and Respiratory Medicine
  • Neurology
  • Medicine(all)

Cite this

Distinctive patterns of cortical excitability to transcranial magnetic stimulation in obstructive sleep apnea syndrome, restless legs syndrome, insomnia, and sleep deprivation. / Lanza, Giuseppe; Cantone, Mariagiovanna; Lanuzza, Bartolo; Pennisi, Manuela; Bella, Rita; Pennisi, Giovanni; Ferri, Raffaele.

In: Sleep Medicine Reviews, Vol. 19, 01.02.2015, p. 39-50.

Research output: Contribution to journalArticle

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