Distinguishing forms of generalized epilepsy using magnetic brain stimulation

Maria Donatella Caramia, Gianluigi Gigli, Cesare Iani, Maria Teresa Desiato, Marina Diomedi, Maria Giuseppina Palmieri, Giorgio Bernardi

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

In this study, we have used paired transcranial stimulation of the motor cortex to test the hypothesis that cortical inhibition is decreased in juvenile myoclonic epilepsy (JME). The double shock technique was adopted here because it offers a means for highlighting abnormal inhibitory mechanisms. From previous experiments performed on healthy subjects, it is known that a magnetic conditioning stimulus, of subthreshold intensity, suppresses the MEP in response to a subsequent suprathreshold stimulus delivered after 1-4 msec. JME patients were selected as a potential contrast with other forms of idiopathic generalized epilepsy, because they complain of myoclonic jerks without loss of consciousness, indicating with certainty a dysfunction of the motor cortex. Two patients with sporadic grand mal and one non-epileptic patient were also investigated. Paired stimulation was produced by a Bi-stim (Magstim) stimulator, with a figure-of-8 coil placed over the hand area of the motor cortex, and a set of interstimulus intervals (ISIs) ranging from 1 to 6 msec was analyzed. In JME patients there were two indications of abnormality with respect to normal subjects and to the other epileptic patients: (l) the absence of MEP suppression to paired stimulation; (2) a progressive amplitude increase of MEPs to the test stimulus alone. In the two patients with the other form of epilepsy the pattern of inhibition was broadly preserved, even though there was some difference from the normal profile. The results suggest that the loss-of MEP inhibition can be regarded as a marker of JME.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalElectroencephalography and Clinical Neurophysiology
Volume98
Issue number1
DOIs
Publication statusPublished - Jan 1996

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Generalized Epilepsy
Juvenile Myoclonic Epilepsy
Motor Cortex
Brain
Myoclonus
Unconsciousness
Shock
Epilepsy
Healthy Volunteers
Hand

Keywords

  • Cortical inhibition
  • Generalized epilepsy
  • Magnetic brain stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Caramia, M. D., Gigli, G., Iani, C., Desiato, M. T., Diomedi, M., Palmieri, M. G., & Bernardi, G. (1996). Distinguishing forms of generalized epilepsy using magnetic brain stimulation. Electroencephalography and Clinical Neurophysiology, 98(1), 14-19. https://doi.org/10.1016/0013-4694(95)00150-6

Distinguishing forms of generalized epilepsy using magnetic brain stimulation. / Caramia, Maria Donatella; Gigli, Gianluigi; Iani, Cesare; Desiato, Maria Teresa; Diomedi, Marina; Palmieri, Maria Giuseppina; Bernardi, Giorgio.

In: Electroencephalography and Clinical Neurophysiology, Vol. 98, No. 1, 01.1996, p. 14-19.

Research output: Contribution to journalArticle

Caramia, MD, Gigli, G, Iani, C, Desiato, MT, Diomedi, M, Palmieri, MG & Bernardi, G 1996, 'Distinguishing forms of generalized epilepsy using magnetic brain stimulation', Electroencephalography and Clinical Neurophysiology, vol. 98, no. 1, pp. 14-19. https://doi.org/10.1016/0013-4694(95)00150-6
Caramia, Maria Donatella ; Gigli, Gianluigi ; Iani, Cesare ; Desiato, Maria Teresa ; Diomedi, Marina ; Palmieri, Maria Giuseppina ; Bernardi, Giorgio. / Distinguishing forms of generalized epilepsy using magnetic brain stimulation. In: Electroencephalography and Clinical Neurophysiology. 1996 ; Vol. 98, No. 1. pp. 14-19.
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