Distribution and localization of p-hydroxy-d-amphetamine in rat brain

Armanda Jori, Silvio Caccia, Giovanna Guiso, Silvio Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

p-Hydroxy-d-amphetamine (p-OHdA) penetrates the blood-brain barrier poorly, when given acutely or by repeated systemic treatments, or when formed by biotransformation from administered d-amphetamine. However its distribution is relatively selective as it accumulates in the striatum more than in the brainstem. The rate of disappearance also differs in the two areas, being slower in the striatum than in the brainstem. These findings suggest that p-OHdA might be stored in different compartments. To check whether p-OHdA specifically accumulated in nerve terminals, catecholaminergic nerve endings were destroyed with 6-hydroxydopamine (6-OHDA). It has been shown that p-OHdA accumulates much less in the striatum of 6-OHDA-treated rats than of controls. This effect was not present in the brainstem. Accumulation of p-OHdA was similar after repeated d-amphetamine administration. The results are interpreted as showing that p-OHdA tends to accumulate in dopaminergic structures.

Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalEuropean Journal of Pharmacology
Volume52
Issue number3-4
DOIs
Publication statusPublished - Dec 1 1978

Keywords

  • 6-Hydroxydopamine
  • Dopamine nerve endings
  • p-Hydroxy-d-amphetamine
  • Selective localisation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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