Distribution and properties of Fc receptors for IgG on different leucocyte populations in man

M. Colombatti, D. Heumann, L. Moretta

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution and some characteristics of Fc receptors for immunoglobulin (FcγR) were analysed on different human leucocyte populations. Interaction of FcγR present on Tγ cells with ox erythrocytes-IgG immune complexes (IgG-IC) provides a switch-off signal for the expression of the FcγR themselves; in addition, these receptors are sensitive to the proteolytic activity of pronase. Since both of these phenomena could have important effects on certain functional activities of the cells, we have analysed the effect of the interaction between IgG-OxE and the FcγR present on various leucocyte populations. The large majority of Tγ cells or of tonsil B cells lost their FcγR after interaction with IC; IC, in turn, had no effect on the FcγR of AC and PMN. Twelve to 22% of the non-T, non-AC fractions retained surface FcγR. Enzymatic treatment of the cells showed that T cells, non-T, non-AC and B cells have FcγR sensitive to pronase, whereas FcγR present on AC and PMN are resistant even to very high concentrations of the enzyme.

Original languageEnglish
Pages (from-to)453-458
Number of pages6
JournalClinical and Experimental Immunology
Volume46
Issue number2
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Immunology

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