We studied the in vivo fate of CD8+ lymphocytes, of naive (CD8+CD45RCbright) or memory (CD8+CD45RC dim) phenotype, injected in syngeneic rats, after their sorting and labeling with [99mTc] HM-PAO. By using the scintigrafic method we showed that memory CD8+ lymphocytes were able to recirculate into liver and lungs. The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats.
- Cell homing
ASJC Scopus subject areas
- Cancer Research
- Molecular Medicine
- Radiology Nuclear Medicine and imaging