Distribution of 99mTc-labeled lymphocytes in control and inflamed rats

Alessandro Fulgenzi, Rosangela Casati, Fabio Riccardo Colombo, Massimo Gasparini, Elisabetta Ferrero, Attilio Bondanza, Paolo Gerundini, Maria Elena Ferrero

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the in vivo fate of CD8+ lymphocytes, of naive (CD8+CD45RCbright) or memory (CD8+CD45RC dim) phenotype, injected in syngeneic rats, after their sorting and labeling with [99mTc] HM-PAO. By using the scintigrafic method we showed that memory CD8+ lymphocytes were able to recirculate into liver and lungs. The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats.

Original languageEnglish
Pages (from-to)631-638
Number of pages8
JournalNuclear Medicine and Biology
Volume31
Issue number5
DOIs
Publication statusPublished - Jul 2004

Keywords

  • Cell homing
  • Inflammation
  • Lymphocytes
  • Rat
  • Scintigraphy

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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