The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarctions treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.
|Number of pages||3|
|Publication status||Published - 1987|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine