Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration

E. Barbieri; R. Latini; V. D'Aranno; A. Fabbri; P. Zampieri; G. P. Trevi; P. Zardini

Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration

E. Barbieri, R. Latini, V. D'Aranno, A. Fabbri, P. Zampieri, G. P. Trevi, P. Zardini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarctions treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.

Original language	English
Pages (from-to)	674-676
Number of pages	3
Journal	Clinical Cardiology
Volume	10
Issue number	11
Publication status	Published - 1987

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration",

abstract = "The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarctions treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.",

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AU - Barbieri, E.

AU - Latini, R.

AU - D'Aranno, V.

AU - Fabbri, A.

AU - Zampieri, P.

AU - Trevi, G. P.

AU - Zardini, P.

PY - 1987

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N2 - The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarctions treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.

AB - The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarctions treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.

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Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration

Abstract

ASJC Scopus subject areas

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