Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration

E. Barbieri, R. Latini, V. D'Aranno, A. Fabbri, P. Zampieri, G. P. Trevi, P. Zardini

Research output: Contribution to journalArticle

Abstract

The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarctions treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.

Original languageEnglish
Pages (from-to)674-676
Number of pages3
JournalClinical Cardiology
Volume10
Issue number11
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Barbieri, E., Latini, R., D'Aranno, V., Fabbri, A., Zampieri, P., Trevi, G. P., & Zardini, P. (1987). Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration. Clinical Cardiology, 10(11), 674-676.