Abstract
The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarctions treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.
| Original language | English |
|---|---|
| Pages (from-to) | 674-676 |
| Number of pages | 3 |
| Journal | Clinical Cardiology |
| Volume | 10 |
| Issue number | 11 |
| Publication status | Published - 1987 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine