Abstract
Total CoQ10 levels were evaluated in whole blood and in plasma obtained from a group of 83 healthy donors. Extraction with light petroleum ether/methanol was more efficient, for whole blood, than the extraction which is often used for plasma and serum, i.e., ethanol hexane. An excellent correlation was present between plasma CoQ10 and whole blood CoQ10. CoQ10 is mainly associated with plasma rather than with cellular components. Positive, significant correlations were found between the LDL- chol/CoQ10 ratio and the total-chol/HDL-chol ratio, which is usually considered a risk factor for atherosclerosis. The proportion of CoQ10 carried by LDL was 58 ± 10%, while the amount carried by HDL was 26 ± 8%. In VLDL + IDL CoQ10 was 16 ± 8%. The content of CoQ10 in single classes of lipoproteins is strictly correlated with CoQ10 plasma concentration. In a parallel study conducted on a population of diabetic patients (one IDDM group and one NIDDM) CoQ10 plasma levels were generally higher compared to the control group, also when normalised to total cholesterol. In particular the LDL fraction showed a CoQ10/chol ratio higher in NIDDM but not in IDDM patients, compared to controls. The CoQ10/triglycerides ratio was lower in NIDDM respect to controls and even lower in IDDM patients.
| Original language | English |
|---|---|
| Pages (from-to) | 231-240 |
| Number of pages | 10 |
| Journal | BioFactors |
| Volume | 9 |
| Issue number | 2-4 |
| Publication status | Published - 1999 |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Distribution of antioxidants among blood components and lipoproteins : Significance of lipids/CoQ10 ratio as a possible marker of increased risk for atherosclerosis. / Tomasetti, Marco; Alleva, Renata; Solenghi, Maria Diana; Littarru, Gian Paolo.
In: BioFactors, Vol. 9, No. 2-4, 1999, p. 231-240.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distribution of antioxidants among blood components and lipoproteins
T2 - Significance of lipids/CoQ10 ratio as a possible marker of increased risk for atherosclerosis
AU - Tomasetti, Marco
AU - Alleva, Renata
AU - Solenghi, Maria Diana
AU - Littarru, Gian Paolo
PY - 1999
Y1 - 1999
N2 - Total CoQ10 levels were evaluated in whole blood and in plasma obtained from a group of 83 healthy donors. Extraction with light petroleum ether/methanol was more efficient, for whole blood, than the extraction which is often used for plasma and serum, i.e., ethanol hexane. An excellent correlation was present between plasma CoQ10 and whole blood CoQ10. CoQ10 is mainly associated with plasma rather than with cellular components. Positive, significant correlations were found between the LDL- chol/CoQ10 ratio and the total-chol/HDL-chol ratio, which is usually considered a risk factor for atherosclerosis. The proportion of CoQ10 carried by LDL was 58 ± 10%, while the amount carried by HDL was 26 ± 8%. In VLDL + IDL CoQ10 was 16 ± 8%. The content of CoQ10 in single classes of lipoproteins is strictly correlated with CoQ10 plasma concentration. In a parallel study conducted on a population of diabetic patients (one IDDM group and one NIDDM) CoQ10 plasma levels were generally higher compared to the control group, also when normalised to total cholesterol. In particular the LDL fraction showed a CoQ10/chol ratio higher in NIDDM but not in IDDM patients, compared to controls. The CoQ10/triglycerides ratio was lower in NIDDM respect to controls and even lower in IDDM patients.
AB - Total CoQ10 levels were evaluated in whole blood and in plasma obtained from a group of 83 healthy donors. Extraction with light petroleum ether/methanol was more efficient, for whole blood, than the extraction which is often used for plasma and serum, i.e., ethanol hexane. An excellent correlation was present between plasma CoQ10 and whole blood CoQ10. CoQ10 is mainly associated with plasma rather than with cellular components. Positive, significant correlations were found between the LDL- chol/CoQ10 ratio and the total-chol/HDL-chol ratio, which is usually considered a risk factor for atherosclerosis. The proportion of CoQ10 carried by LDL was 58 ± 10%, while the amount carried by HDL was 26 ± 8%. In VLDL + IDL CoQ10 was 16 ± 8%. The content of CoQ10 in single classes of lipoproteins is strictly correlated with CoQ10 plasma concentration. In a parallel study conducted on a population of diabetic patients (one IDDM group and one NIDDM) CoQ10 plasma levels were generally higher compared to the control group, also when normalised to total cholesterol. In particular the LDL fraction showed a CoQ10/chol ratio higher in NIDDM but not in IDDM patients, compared to controls. The CoQ10/triglycerides ratio was lower in NIDDM respect to controls and even lower in IDDM patients.
UR - http://www.scopus.com/inward/record.url?scp=0033067363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033067363&partnerID=8YFLogxK
M3 - Article
C2 - 10416035
AN - SCOPUS:0033067363
VL - 9
SP - 231
EP - 240
JO - BioFactors
JF - BioFactors
SN - 0951-6433
IS - 2-4
ER -