Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren

S. Gallus, L. Naldi, Maurizio Leardini, Marialisa Feliciangeli, Danilo Assalve, Luca Stingeni, Ignazio Stanganelli, Serena Magi, Francesco Cusano, Giovanni Sarracco, Anna Di Landro, Giovanni Lo Scocco, Vito Di Lernia, Giampaolo Tessari, Gianfranco Fenizi, Andrea Altobella, Paolo Carli, Paolo Nardini, Vincenzo De Giorgi, Enrico PezzarossaRossella Morelli, Antonella Frassetto, Andreina Cellini, Oriana Simonetti, Annamaria Offidani, Annarosa Virgili, Maria Rosaria Zampino, Pietroandrea Villano, Anna Ausilia, Sonia Ferraiolo, Concetta Flaminio, Francesco Tripodi-Cutrì, Raffaele Filotico, Maria Ester Lassandro

Research output: Contribution to journalArticle

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Abstract

Background: Scanty information is available on the prevalence of congenital melanocytic naevi (CMN) and congenital naevus-like naevi (CNLN), particularly the small ones. Objectives: To estimate the prevalence of CMN/CNLN in Italian schoolchildren, and to assess variations according to potential risk factors for melanoma. Methods: We conducted a survey in 13 Italian areas on 3406 schoolchildren aged 12-17 years. Children were examined by dermatologists who assessed pigmentary traits and made a count of small (6-15 mm in diameter) and medium/large (> 15 mm) CMN/CNLN on 19 anatomical areas. Results: Overall, 592 children (17.4%) had one or more CMN/CNLN. Prevalence of small CMN/CNLN was 16.1%, and that of medium/large CMN/CNLN was 1.8%. There was no difference between age groups and sexes. CMN/CNLN were more frequent in children with a higher number of common melanocytic naevi (multivariate odds ratio, OR = 7.1 for the highest vs. the lowest quartile), consistent in small (OR = 7.2) and medium/large CMN/CNLN (OR = 6.0). Family history of malignant melanoma (OR = 1.4) and personal history of diabetes (OR = 4.4) appeared to be directly, and sun exposure inversely associated with CMN/CNLN. No relation was evident between CMN/CNLN and pigmentary traits, anthropometric characteristics, dietary habits, freckles, sunburns, sunscreen use or history of selected diseases. Conclusions: The association with family history of melanoma, the strong association with acquired melanocytic naevi, and the lack of association with pigmentary traits and sunburns suggest that CMN/CNLN may act as an independent risk marker for subjects at increased risk for cutaneous melanoma later in life.

Original languageEnglish
Pages (from-to)433-438
Number of pages6
JournalBritish Journal of Dermatology
Volume159
Issue number2
DOIs
Publication statusPublished - Aug 2008

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Pigmented Nevus
Nevus
Melanoma
Surveys and Questionnaires
Sunburn

Keywords

  • Children
  • Congenital naevus
  • Congenital naevus-like naevi
  • Italy
  • Survey

ASJC Scopus subject areas

  • Dermatology

Cite this

Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren. / Gallus, S.; Naldi, L.; Leardini, Maurizio; Feliciangeli, Marialisa; Assalve, Danilo; Stingeni, Luca; Stanganelli, Ignazio; Magi, Serena; Cusano, Francesco; Sarracco, Giovanni; Di Landro, Anna; Lo Scocco, Giovanni; Di Lernia, Vito; Tessari, Giampaolo; Fenizi, Gianfranco; Altobella, Andrea; Carli, Paolo; Nardini, Paolo; De Giorgi, Vincenzo; Pezzarossa, Enrico; Morelli, Rossella; Frassetto, Antonella; Cellini, Andreina; Simonetti, Oriana; Offidani, Annamaria; Virgili, Annarosa; Zampino, Maria Rosaria; Villano, Pietroandrea; Ausilia, Anna; Ferraiolo, Sonia; Flaminio, Concetta; Tripodi-Cutrì, Francesco; Filotico, Raffaele; Lassandro, Maria Ester.

In: British Journal of Dermatology, Vol. 159, No. 2, 08.2008, p. 433-438.

Research output: Contribution to journalArticle

Gallus, S, Naldi, L, Leardini, M, Feliciangeli, M, Assalve, D, Stingeni, L, Stanganelli, I, Magi, S, Cusano, F, Sarracco, G, Di Landro, A, Lo Scocco, G, Di Lernia, V, Tessari, G, Fenizi, G, Altobella, A, Carli, P, Nardini, P, De Giorgi, V, Pezzarossa, E, Morelli, R, Frassetto, A, Cellini, A, Simonetti, O, Offidani, A, Virgili, A, Zampino, MR, Villano, P, Ausilia, A, Ferraiolo, S, Flaminio, C, Tripodi-Cutrì, F, Filotico, R & Lassandro, ME 2008, 'Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren', British Journal of Dermatology, vol. 159, no. 2, pp. 433-438. https://doi.org/10.1111/j.1365-2133.2008.08656.x
Gallus, S. ; Naldi, L. ; Leardini, Maurizio ; Feliciangeli, Marialisa ; Assalve, Danilo ; Stingeni, Luca ; Stanganelli, Ignazio ; Magi, Serena ; Cusano, Francesco ; Sarracco, Giovanni ; Di Landro, Anna ; Lo Scocco, Giovanni ; Di Lernia, Vito ; Tessari, Giampaolo ; Fenizi, Gianfranco ; Altobella, Andrea ; Carli, Paolo ; Nardini, Paolo ; De Giorgi, Vincenzo ; Pezzarossa, Enrico ; Morelli, Rossella ; Frassetto, Antonella ; Cellini, Andreina ; Simonetti, Oriana ; Offidani, Annamaria ; Virgili, Annarosa ; Zampino, Maria Rosaria ; Villano, Pietroandrea ; Ausilia, Anna ; Ferraiolo, Sonia ; Flaminio, Concetta ; Tripodi-Cutrì, Francesco ; Filotico, Raffaele ; Lassandro, Maria Ester. / Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren. In: British Journal of Dermatology. 2008 ; Vol. 159, No. 2. pp. 433-438.
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title = "Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren",
abstract = "Background: Scanty information is available on the prevalence of congenital melanocytic naevi (CMN) and congenital naevus-like naevi (CNLN), particularly the small ones. Objectives: To estimate the prevalence of CMN/CNLN in Italian schoolchildren, and to assess variations according to potential risk factors for melanoma. Methods: We conducted a survey in 13 Italian areas on 3406 schoolchildren aged 12-17 years. Children were examined by dermatologists who assessed pigmentary traits and made a count of small (6-15 mm in diameter) and medium/large (> 15 mm) CMN/CNLN on 19 anatomical areas. Results: Overall, 592 children (17.4{\%}) had one or more CMN/CNLN. Prevalence of small CMN/CNLN was 16.1{\%}, and that of medium/large CMN/CNLN was 1.8{\%}. There was no difference between age groups and sexes. CMN/CNLN were more frequent in children with a higher number of common melanocytic naevi (multivariate odds ratio, OR = 7.1 for the highest vs. the lowest quartile), consistent in small (OR = 7.2) and medium/large CMN/CNLN (OR = 6.0). Family history of malignant melanoma (OR = 1.4) and personal history of diabetes (OR = 4.4) appeared to be directly, and sun exposure inversely associated with CMN/CNLN. No relation was evident between CMN/CNLN and pigmentary traits, anthropometric characteristics, dietary habits, freckles, sunburns, sunscreen use or history of selected diseases. Conclusions: The association with family history of melanoma, the strong association with acquired melanocytic naevi, and the lack of association with pigmentary traits and sunburns suggest that CMN/CNLN may act as an independent risk marker for subjects at increased risk for cutaneous melanoma later in life.",
keywords = "Children, Congenital naevus, Congenital naevus-like naevi, Italy, Survey",
author = "S. Gallus and L. Naldi and Maurizio Leardini and Marialisa Feliciangeli and Danilo Assalve and Luca Stingeni and Ignazio Stanganelli and Serena Magi and Francesco Cusano and Giovanni Sarracco and {Di Landro}, Anna and {Lo Scocco}, Giovanni and {Di Lernia}, Vito and Giampaolo Tessari and Gianfranco Fenizi and Andrea Altobella and Paolo Carli and Paolo Nardini and {De Giorgi}, Vincenzo and Enrico Pezzarossa and Rossella Morelli and Antonella Frassetto and Andreina Cellini and Oriana Simonetti and Annamaria Offidani and Annarosa Virgili and Zampino, {Maria Rosaria} and Pietroandrea Villano and Anna Ausilia and Sonia Ferraiolo and Concetta Flaminio and Francesco Tripodi-Cutr{\`i} and Raffaele Filotico and Lassandro, {Maria Ester}",
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TY - JOUR

T1 - Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren

AU - Gallus, S.

AU - Naldi, L.

AU - Leardini, Maurizio

AU - Feliciangeli, Marialisa

AU - Assalve, Danilo

AU - Stingeni, Luca

AU - Stanganelli, Ignazio

AU - Magi, Serena

AU - Cusano, Francesco

AU - Sarracco, Giovanni

AU - Di Landro, Anna

AU - Lo Scocco, Giovanni

AU - Di Lernia, Vito

AU - Tessari, Giampaolo

AU - Fenizi, Gianfranco

AU - Altobella, Andrea

AU - Carli, Paolo

AU - Nardini, Paolo

AU - De Giorgi, Vincenzo

AU - Pezzarossa, Enrico

AU - Morelli, Rossella

AU - Frassetto, Antonella

AU - Cellini, Andreina

AU - Simonetti, Oriana

AU - Offidani, Annamaria

AU - Virgili, Annarosa

AU - Zampino, Maria Rosaria

AU - Villano, Pietroandrea

AU - Ausilia, Anna

AU - Ferraiolo, Sonia

AU - Flaminio, Concetta

AU - Tripodi-Cutrì, Francesco

AU - Filotico, Raffaele

AU - Lassandro, Maria Ester

PY - 2008/8

Y1 - 2008/8

N2 - Background: Scanty information is available on the prevalence of congenital melanocytic naevi (CMN) and congenital naevus-like naevi (CNLN), particularly the small ones. Objectives: To estimate the prevalence of CMN/CNLN in Italian schoolchildren, and to assess variations according to potential risk factors for melanoma. Methods: We conducted a survey in 13 Italian areas on 3406 schoolchildren aged 12-17 years. Children were examined by dermatologists who assessed pigmentary traits and made a count of small (6-15 mm in diameter) and medium/large (> 15 mm) CMN/CNLN on 19 anatomical areas. Results: Overall, 592 children (17.4%) had one or more CMN/CNLN. Prevalence of small CMN/CNLN was 16.1%, and that of medium/large CMN/CNLN was 1.8%. There was no difference between age groups and sexes. CMN/CNLN were more frequent in children with a higher number of common melanocytic naevi (multivariate odds ratio, OR = 7.1 for the highest vs. the lowest quartile), consistent in small (OR = 7.2) and medium/large CMN/CNLN (OR = 6.0). Family history of malignant melanoma (OR = 1.4) and personal history of diabetes (OR = 4.4) appeared to be directly, and sun exposure inversely associated with CMN/CNLN. No relation was evident between CMN/CNLN and pigmentary traits, anthropometric characteristics, dietary habits, freckles, sunburns, sunscreen use or history of selected diseases. Conclusions: The association with family history of melanoma, the strong association with acquired melanocytic naevi, and the lack of association with pigmentary traits and sunburns suggest that CMN/CNLN may act as an independent risk marker for subjects at increased risk for cutaneous melanoma later in life.

AB - Background: Scanty information is available on the prevalence of congenital melanocytic naevi (CMN) and congenital naevus-like naevi (CNLN), particularly the small ones. Objectives: To estimate the prevalence of CMN/CNLN in Italian schoolchildren, and to assess variations according to potential risk factors for melanoma. Methods: We conducted a survey in 13 Italian areas on 3406 schoolchildren aged 12-17 years. Children were examined by dermatologists who assessed pigmentary traits and made a count of small (6-15 mm in diameter) and medium/large (> 15 mm) CMN/CNLN on 19 anatomical areas. Results: Overall, 592 children (17.4%) had one or more CMN/CNLN. Prevalence of small CMN/CNLN was 16.1%, and that of medium/large CMN/CNLN was 1.8%. There was no difference between age groups and sexes. CMN/CNLN were more frequent in children with a higher number of common melanocytic naevi (multivariate odds ratio, OR = 7.1 for the highest vs. the lowest quartile), consistent in small (OR = 7.2) and medium/large CMN/CNLN (OR = 6.0). Family history of malignant melanoma (OR = 1.4) and personal history of diabetes (OR = 4.4) appeared to be directly, and sun exposure inversely associated with CMN/CNLN. No relation was evident between CMN/CNLN and pigmentary traits, anthropometric characteristics, dietary habits, freckles, sunburns, sunscreen use or history of selected diseases. Conclusions: The association with family history of melanoma, the strong association with acquired melanocytic naevi, and the lack of association with pigmentary traits and sunburns suggest that CMN/CNLN may act as an independent risk marker for subjects at increased risk for cutaneous melanoma later in life.

KW - Children

KW - Congenital naevus

KW - Congenital naevus-like naevi

KW - Italy

KW - Survey

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U2 - 10.1111/j.1365-2133.2008.08656.x

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