Abstract
Background: Scanty information is available on the prevalence of congenital melanocytic naevi (CMN) and congenital naevus-like naevi (CNLN), particularly the small ones. Objectives: To estimate the prevalence of CMN/CNLN in Italian schoolchildren, and to assess variations according to potential risk factors for melanoma. Methods: We conducted a survey in 13 Italian areas on 3406 schoolchildren aged 12-17 years. Children were examined by dermatologists who assessed pigmentary traits and made a count of small (6-15 mm in diameter) and medium/large (> 15 mm) CMN/CNLN on 19 anatomical areas. Results: Overall, 592 children (17.4%) had one or more CMN/CNLN. Prevalence of small CMN/CNLN was 16.1%, and that of medium/large CMN/CNLN was 1.8%. There was no difference between age groups and sexes. CMN/CNLN were more frequent in children with a higher number of common melanocytic naevi (multivariate odds ratio, OR = 7.1 for the highest vs. the lowest quartile), consistent in small (OR = 7.2) and medium/large CMN/CNLN (OR = 6.0). Family history of malignant melanoma (OR = 1.4) and personal history of diabetes (OR = 4.4) appeared to be directly, and sun exposure inversely associated with CMN/CNLN. No relation was evident between CMN/CNLN and pigmentary traits, anthropometric characteristics, dietary habits, freckles, sunburns, sunscreen use or history of selected diseases. Conclusions: The association with family history of melanoma, the strong association with acquired melanocytic naevi, and the lack of association with pigmentary traits and sunburns suggest that CMN/CNLN may act as an independent risk marker for subjects at increased risk for cutaneous melanoma later in life.
| Original language | English |
|---|---|
| Pages (from-to) | 433-438 |
| Number of pages | 6 |
| Journal | British Journal of Dermatology |
| Volume | 159 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2008 |
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Keywords
- Children
- Congenital naevus
- Congenital naevus-like naevi
- Italy
- Survey
ASJC Scopus subject areas
- Dermatology
Cite this
Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren. / Gallus, S.; Naldi, L.; Leardini, Maurizio; Feliciangeli, Marialisa; Assalve, Danilo; Stingeni, Luca; Stanganelli, Ignazio; Magi, Serena; Cusano, Francesco; Sarracco, Giovanni; Di Landro, Anna; Lo Scocco, Giovanni; Di Lernia, Vito; Tessari, Giampaolo; Fenizi, Gianfranco; Altobella, Andrea; Carli, Paolo; Nardini, Paolo; De Giorgi, Vincenzo; Pezzarossa, Enrico; Morelli, Rossella; Frassetto, Antonella; Cellini, Andreina; Simonetti, Oriana; Offidani, Annamaria; Virgili, Annarosa; Zampino, Maria Rosaria; Villano, Pietroandrea; Ausilia, Anna; Ferraiolo, Sonia; Flaminio, Concetta; Tripodi-Cutrì, Francesco; Filotico, Raffaele; Lassandro, Maria Ester.
In: British Journal of Dermatology, Vol. 159, No. 2, 08.2008, p. 433-438.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren
AU - Gallus, S.
AU - Naldi, L.
AU - Leardini, Maurizio
AU - Feliciangeli, Marialisa
AU - Assalve, Danilo
AU - Stingeni, Luca
AU - Stanganelli, Ignazio
AU - Magi, Serena
AU - Cusano, Francesco
AU - Sarracco, Giovanni
AU - Di Landro, Anna
AU - Lo Scocco, Giovanni
AU - Di Lernia, Vito
AU - Tessari, Giampaolo
AU - Fenizi, Gianfranco
AU - Altobella, Andrea
AU - Carli, Paolo
AU - Nardini, Paolo
AU - De Giorgi, Vincenzo
AU - Pezzarossa, Enrico
AU - Morelli, Rossella
AU - Frassetto, Antonella
AU - Cellini, Andreina
AU - Simonetti, Oriana
AU - Offidani, Annamaria
AU - Virgili, Annarosa
AU - Zampino, Maria Rosaria
AU - Villano, Pietroandrea
AU - Ausilia, Anna
AU - Ferraiolo, Sonia
AU - Flaminio, Concetta
AU - Tripodi-Cutrì, Francesco
AU - Filotico, Raffaele
AU - Lassandro, Maria Ester
PY - 2008/8
Y1 - 2008/8
N2 - Background: Scanty information is available on the prevalence of congenital melanocytic naevi (CMN) and congenital naevus-like naevi (CNLN), particularly the small ones. Objectives: To estimate the prevalence of CMN/CNLN in Italian schoolchildren, and to assess variations according to potential risk factors for melanoma. Methods: We conducted a survey in 13 Italian areas on 3406 schoolchildren aged 12-17 years. Children were examined by dermatologists who assessed pigmentary traits and made a count of small (6-15 mm in diameter) and medium/large (> 15 mm) CMN/CNLN on 19 anatomical areas. Results: Overall, 592 children (17.4%) had one or more CMN/CNLN. Prevalence of small CMN/CNLN was 16.1%, and that of medium/large CMN/CNLN was 1.8%. There was no difference between age groups and sexes. CMN/CNLN were more frequent in children with a higher number of common melanocytic naevi (multivariate odds ratio, OR = 7.1 for the highest vs. the lowest quartile), consistent in small (OR = 7.2) and medium/large CMN/CNLN (OR = 6.0). Family history of malignant melanoma (OR = 1.4) and personal history of diabetes (OR = 4.4) appeared to be directly, and sun exposure inversely associated with CMN/CNLN. No relation was evident between CMN/CNLN and pigmentary traits, anthropometric characteristics, dietary habits, freckles, sunburns, sunscreen use or history of selected diseases. Conclusions: The association with family history of melanoma, the strong association with acquired melanocytic naevi, and the lack of association with pigmentary traits and sunburns suggest that CMN/CNLN may act as an independent risk marker for subjects at increased risk for cutaneous melanoma later in life.
AB - Background: Scanty information is available on the prevalence of congenital melanocytic naevi (CMN) and congenital naevus-like naevi (CNLN), particularly the small ones. Objectives: To estimate the prevalence of CMN/CNLN in Italian schoolchildren, and to assess variations according to potential risk factors for melanoma. Methods: We conducted a survey in 13 Italian areas on 3406 schoolchildren aged 12-17 years. Children were examined by dermatologists who assessed pigmentary traits and made a count of small (6-15 mm in diameter) and medium/large (> 15 mm) CMN/CNLN on 19 anatomical areas. Results: Overall, 592 children (17.4%) had one or more CMN/CNLN. Prevalence of small CMN/CNLN was 16.1%, and that of medium/large CMN/CNLN was 1.8%. There was no difference between age groups and sexes. CMN/CNLN were more frequent in children with a higher number of common melanocytic naevi (multivariate odds ratio, OR = 7.1 for the highest vs. the lowest quartile), consistent in small (OR = 7.2) and medium/large CMN/CNLN (OR = 6.0). Family history of malignant melanoma (OR = 1.4) and personal history of diabetes (OR = 4.4) appeared to be directly, and sun exposure inversely associated with CMN/CNLN. No relation was evident between CMN/CNLN and pigmentary traits, anthropometric characteristics, dietary habits, freckles, sunburns, sunscreen use or history of selected diseases. Conclusions: The association with family history of melanoma, the strong association with acquired melanocytic naevi, and the lack of association with pigmentary traits and sunburns suggest that CMN/CNLN may act as an independent risk marker for subjects at increased risk for cutaneous melanoma later in life.
KW - Children
KW - Congenital naevus
KW - Congenital naevus-like naevi
KW - Italy
KW - Survey
UR - http://www.scopus.com/inward/record.url?scp=47549117897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47549117897&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2133.2008.08656.x
DO - 10.1111/j.1365-2133.2008.08656.x
M3 - Article
C2 - 18547318
AN - SCOPUS:47549117897
VL - 159
SP - 433
EP - 438
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 2
ER -