Abstract
Concentrations of fenfluramine and its metabolite, norfenfluramine, were measured in blood, brain and parametrial adipose tissues 15, 30, 60 and 120 min after intraperitoneal (i.p.) administration of fenfluramine hydrochloride (10 mg/kg) to normal and gold-thioglucose obese mice. Concentrations of fenfluramine were higher in the brain of obese mice than in normal mice, while there was no difference in norfenfluramine levels in the two groups. This difference may be related to higher blood levels of fenfluramine but not of norfenfluramine in obese animals. The drug was presented in about the same concentrations in the adipose tissue of the two groups. These results may explain previous findings that fenfluramine was more effective as an anorectic agent in obese than in lean mice.
| Original language | English |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | International Journal of Obesity |
| Volume | 2 |
| Issue number | 1 |
| Publication status | Published - 1978 |
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ASJC Scopus subject areas
- Food Science
- Endocrinology
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Public Health, Environmental and Occupational Health
Cite this
Distribution of fenfluramine in normal and obese mice. / Bizzi, A.; Tacconi, M. T.; Tognoni, G.; Morselli, P. L.; Garattini, S.
In: International Journal of Obesity, Vol. 2, No. 1, 1978, p. 1-5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distribution of fenfluramine in normal and obese mice.
AU - Bizzi, A.
AU - Tacconi, M. T.
AU - Tognoni, G.
AU - Morselli, P. L.
AU - Garattini, S.
PY - 1978
Y1 - 1978
N2 - Concentrations of fenfluramine and its metabolite, norfenfluramine, were measured in blood, brain and parametrial adipose tissues 15, 30, 60 and 120 min after intraperitoneal (i.p.) administration of fenfluramine hydrochloride (10 mg/kg) to normal and gold-thioglucose obese mice. Concentrations of fenfluramine were higher in the brain of obese mice than in normal mice, while there was no difference in norfenfluramine levels in the two groups. This difference may be related to higher blood levels of fenfluramine but not of norfenfluramine in obese animals. The drug was presented in about the same concentrations in the adipose tissue of the two groups. These results may explain previous findings that fenfluramine was more effective as an anorectic agent in obese than in lean mice.
AB - Concentrations of fenfluramine and its metabolite, norfenfluramine, were measured in blood, brain and parametrial adipose tissues 15, 30, 60 and 120 min after intraperitoneal (i.p.) administration of fenfluramine hydrochloride (10 mg/kg) to normal and gold-thioglucose obese mice. Concentrations of fenfluramine were higher in the brain of obese mice than in normal mice, while there was no difference in norfenfluramine levels in the two groups. This difference may be related to higher blood levels of fenfluramine but not of norfenfluramine in obese animals. The drug was presented in about the same concentrations in the adipose tissue of the two groups. These results may explain previous findings that fenfluramine was more effective as an anorectic agent in obese than in lean mice.
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M3 - Article
C2 - 361587
AN - SCOPUS:0018065810
VL - 2
SP - 1
EP - 5
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
IS - 1
ER -