Distribution of GABAB(1a), GABAB(1b) and GABAB2 receptor protein in cerebral cortex and thalamus of adult rats

Alessandra P. Princivalle, Menelas N. Pangalos, Norman G. Bowery, Roberto Spreafico

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The distribution of GABAB receptor subunits GABAB(1a), GABAB(1b) and GABAB2, has been examined in the cerebral cortex and thalamus of adult rats using an immunocytochemical technique. GABAB(1a) and GABAB(1b) subunits co-localized with GABAB2 in the cortex, where afferent thalamic GABAergic axons project to pyramidal neurones. The expression patterns of GABAB(1a), GABAB(1b) and GABAB2 were similar throughout the thalamus. The data suggest that the GABAB(1b) subunit might be the presynaptic isoform in the thalamo-cortical pathway with the GABAB(1a) subunit possibly present at postsynaptic sites on cell bodies. This contrasts with our previous data, obtained in cerebellum and spinal cord which indicate opposite locations. Thus, it seems unlikely that functional role along with cellular location can be assigned in a general manner to specific GABAB receptor subunit splice variants.

Original languageEnglish
Pages (from-to)591-595
Number of pages5
JournalNeuroReport
Volume12
Issue number3
Publication statusPublished - Mar 5 2001

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Thalamus
Cerebral Cortex
Pyramidal Cells
Cerebellum
Axons
Spinal Cord
Protein Isoforms
Proteins
Cell Body

Keywords

  • Ccortex
  • Heteromeric GABA
  • Somatosensory system
  • Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Princivalle, A. P., Pangalos, M. N., Bowery, N. G., & Spreafico, R. (2001). Distribution of GABAB(1a), GABAB(1b) and GABAB2 receptor protein in cerebral cortex and thalamus of adult rats. NeuroReport, 12(3), 591-595.

Distribution of GABAB(1a), GABAB(1b) and GABAB2 receptor protein in cerebral cortex and thalamus of adult rats. / Princivalle, Alessandra P.; Pangalos, Menelas N.; Bowery, Norman G.; Spreafico, Roberto.

In: NeuroReport, Vol. 12, No. 3, 05.03.2001, p. 591-595.

Research output: Contribution to journalArticle

Princivalle, AP, Pangalos, MN, Bowery, NG & Spreafico, R 2001, 'Distribution of GABAB(1a), GABAB(1b) and GABAB2 receptor protein in cerebral cortex and thalamus of adult rats', NeuroReport, vol. 12, no. 3, pp. 591-595.
Princivalle AP, Pangalos MN, Bowery NG, Spreafico R. Distribution of GABAB(1a), GABAB(1b) and GABAB2 receptor protein in cerebral cortex and thalamus of adult rats. NeuroReport. 2001 Mar 5;12(3):591-595.
Princivalle, Alessandra P. ; Pangalos, Menelas N. ; Bowery, Norman G. ; Spreafico, Roberto. / Distribution of GABAB(1a), GABAB(1b) and GABAB2 receptor protein in cerebral cortex and thalamus of adult rats. In: NeuroReport. 2001 ; Vol. 12, No. 3. pp. 591-595.
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