The distribution of GABAB receptor subunits GABAB(1a), GABAB(1b) and GABAB2, has been examined in the cerebral cortex and thalamus of adult rats using an immunocytochemical technique. GABAB(1a) and GABAB(1b) subunits co-localized with GABAB2 in the cortex, where afferent thalamic GABAergic axons project to pyramidal neurones. The expression patterns of GABAB(1a), GABAB(1b) and GABAB2 were similar throughout the thalamus. The data suggest that the GABAB(1b) subunit might be the presynaptic isoform in the thalamo-cortical pathway with the GABAB(1a) subunit possibly present at postsynaptic sites on cell bodies. This contrasts with our previous data, obtained in cerebellum and spinal cord which indicate opposite locations. Thus, it seems unlikely that functional role along with cellular location can be assigned in a general manner to specific GABAB receptor subunit splice variants.
|Number of pages||5|
|Publication status||Published - Mar 5 2001|
- Heteromeric GABA
- Somatosensory system
ASJC Scopus subject areas