Distribution of Ha-RAS-1 proto-oncogene alleles in breast cancer patients and in a control population

Giuseppe Saglio, Clara Camaschella, Maurizia Giai, Anna Serra, Angelo Guerrasio, Bruno Peirone, Paolo Gasparini, Umberto Mazza, Ruggero Ceppellini, Nicoletta Biglia, Paolo Cortese, Piero Sismondi

Research output: Contribution to journalArticlepeer-review

Abstract

The frequencies of 13 different Ha-ras proto-oncogene alleles have been estimated in 92 breast cancer patients and 60 unaffected individuals. The Ha-ras alleles can be identified using a DNA restriction fragment length polymorphism (RFLP) closely linked to the 3′ end of the gene, and are characterized by a different length due to a region of sequences repeated a variable number of times (variable tandem repeats, VTR). The statistical analysis of the data obtained shows that the frequency of alleles ranging between specific length limits is significantly higher in breast cancer patients than in controls. The same applies to specific genotypes bearing the aforementioned alleles. This suggests that the inheritance of these alleles may be associated with an increased risk of developing breast cancer.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalBreast Cancer Research and Treatment
Volume11
Issue number2
DOIs
Publication statusPublished - May 1988

Keywords

  • alleles
  • Ha-ras
  • oncogenes
  • RFLP's

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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