Abstract
A method to measure butyrophenones by gas chromatography was developed and applied to determine these drugs in biological materials. Haloperidol and trifluperidol possess some common properties when injected into rats. They penetrate very rapidly into brain where they reach levels several times higher than in blood. The brain concentration needed to completely inhibit the effects of amphetamine is between 30 and 40 ng/g for both drugs.
Original language | English |
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Pages (from-to) | 427-430 |
Number of pages | 4 |
Journal | Chemico-Biological Interactions |
Volume | 4 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1972 |
ASJC Scopus subject areas
- Toxicology