Distribution of haloperidol and trifluperidol in brain and blood of rats

F. Marcucci, L. Airoldi, E. Mussini, S. Garattini

Research output: Contribution to journalArticle

Abstract

A method to measure butyrophenones by gas chromatography was developed and applied to determine these drugs in biological materials. Haloperidol and trifluperidol possess some common properties when injected into rats. They penetrate very rapidly into brain where they reach levels several times higher than in blood. The brain concentration needed to completely inhibit the effects of amphetamine is between 30 and 40 ng/g for both drugs.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalChemico-Biological Interactions
Volume4
Issue number6
DOIs
Publication statusPublished - 1972

ASJC Scopus subject areas

  • Toxicology

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