Distribution of haloperidol and trifluperidol in brain and blood of rats

F. Marcucci; L. Airoldi; E. Mussini; S. Garattini

doi:10.1016/0009-2797(72)90063-4

Distribution of haloperidol and trifluperidol in brain and blood of rats

F. Marcucci, L. Airoldi, E. Mussini, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

A method to measure butyrophenones by gas chromatography was developed and applied to determine these drugs in biological materials. Haloperidol and trifluperidol possess some common properties when injected into rats. They penetrate very rapidly into brain where they reach levels several times higher than in blood. The brain concentration needed to completely inhibit the effects of amphetamine is between 30 and 40 ng/g for both drugs.

Original language	English
Pages (from-to)	427-430
Number of pages	4
Journal	Chemico-Biological Interactions
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/0009-2797(72)90063-4
Publication status	Published - 1972

ASJC Scopus subject areas

Toxicology

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10.1016/0009-2797(72)90063-4

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title = "Distribution of haloperidol and trifluperidol in brain and blood of rats",

abstract = "A method to measure butyrophenones by gas chromatography was developed and applied to determine these drugs in biological materials. Haloperidol and trifluperidol possess some common properties when injected into rats. They penetrate very rapidly into brain where they reach levels several times higher than in blood. The brain concentration needed to completely inhibit the effects of amphetamine is between 30 and 40 ng/g for both drugs.",

author = "F. Marcucci and L. Airoldi and E. Mussini and S. Garattini",

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AU - Mussini, E.

AU - Garattini, S.

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Distribution of haloperidol and trifluperidol in brain and blood of rats

Abstract

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