Distribution of Kaposi's sarcoma herpesvirus sequences among lymphoid malignancies in Italy and Spain

C. Pastore, A. Gloghini, G. Volpe, J. Nomdedeu, E. Leonardo, U. Mazza, G. Saglio, A. Carbone, G. Gaidano

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we have tested the distribution of Kaposi's sarcoma herpesvirus (KSHV) DNA sequences throughout the spectrum of lymphoid neoplasia in Italy and Spain. 180 cases of lymphoid malignancies representative of the major histologic and immunophenotypic categories of B- and T-ce]l tumours were analysed by means of a polymerase chain reaction-based assay. KSHV sequences were consistently absent in all categories of lymphoid malignancies studied, with the exception of a subset of B-cell non-Hodgkin's lymphomas localizing in the pleural, pericardial or peritoneal cavities, and fulfilling the diagnostic criteria of body-cavity-based lymphoma. The selective and consistent association of KSHV sequences with cases of body-cavity-based lymphoma throughout the spectrum of lymphoid neoplasms suggests that KSHV may be involved in the pathogenesis of this peculiar type of lymphoid malignancy.

Original languageEnglish
Pages (from-to)918-920
Number of pages3
JournalBritish Journal of Haematology
Volume91
Issue number4
Publication statusPublished - 1995

Keywords

  • Acute lymphoblastic leukaemia
  • AIDS
  • Body-cavity-based lymphoma
  • Kaposi's sarcoma herpesvirus
  • non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Distribution of Kaposi's sarcoma herpesvirus sequences among lymphoid malignancies in Italy and Spain'. Together they form a unique fingerprint.

Cite this