Abstract
Naturally occurring resistance-associated variants (RAVs) within the protease domain of hepatitis C virus (HCV) genotype (G) 1a separated into clades 1 and 2, and G1b were investigated in 59 HIV/HCV coinfected patients. RAVs were detected in 10/23 G1a/clade 1 and 1/19 G1b (p 0.0059). A similar frequency of RAVs was found when comparing G1a/clade 2 and G1b (p 0.1672). A cross-resistance to the macrocyclic compounds simeprevir and paritaprevir was detected in two G1a/clade 2 and 1 G1b sequences and none of G1a/clade 1 sequences. The simultaneous characterization of subtype and natural RAVs by population analysis of the NS3 domain by may add important information for anti-HCV treatment strategies including protease inhibitors.
Original language | English |
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Pages (from-to) | 386.e1 - 386.e3 |
Journal | Clinical Microbiology and Infection |
Volume | 22 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 1 2016 |
Keywords
- Clades 1 and 2
- Genotype 1a
- HCV-PI
- HIV
- Natural RAV
- Q80K polymorphism
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases