Distribution of natural resistance to NS3 protease inhibitors in hepatitis C genotype 1a separated into clades 1 and 2 and in genotype 1b of HIV-infected patients

S. Bagaglio; Caterina Uberti Foppa; E. Messina; M. Merli; H. Hasson; A. Andolina; A. Galli; A. Lazzarin; Giulia Morsica

doi:10.1016/j.cmi.2015.12.007

Distribution of natural resistance to NS3 protease inhibitors in hepatitis C genotype 1a separated into clades 1 and 2 and in genotype 1b of HIV-infected patients

S. Bagaglio, Caterina Uberti Foppa, E. Messina, M. Merli, H. Hasson, A. Andolina, A. Galli, A. Lazzarin, Giulia Morsica

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Naturally occurring resistance-associated variants (RAVs) within the protease domain of hepatitis C virus (HCV) genotype (G) 1a separated into clades 1 and 2, and G1b were investigated in 59 HIV/HCV coinfected patients. RAVs were detected in 10/23 G1a/clade 1 and 1/19 G1b (p 0.0059). A similar frequency of RAVs was found when comparing G1a/clade 2 and G1b (p 0.1672). A cross-resistance to the macrocyclic compounds simeprevir and paritaprevir was detected in two G1a/clade 2 and 1 G1b sequences and none of G1a/clade 1 sequences. The simultaneous characterization of subtype and natural RAVs by population analysis of the NS3 domain by may add important information for anti-HCV treatment strategies including protease inhibitors.

Original language	English
Pages (from-to)	386.e1 - 386.e3
Journal	Clinical Microbiology and Infection
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.cmi.2015.12.007
Publication status	Published - Apr 1 2016

Keywords

Clades 1 and 2
Genotype 1a
HCV-PI
HIV
Natural RAV
Q80K polymorphism

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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Bagaglio, S., Uberti Foppa, C., Messina, E., Merli, M., Hasson, H., Andolina, A., Galli, A., Lazzarin, A., & Morsica, G. (2016). Distribution of natural resistance to NS3 protease inhibitors in hepatitis C genotype 1a separated into clades 1 and 2 and in genotype 1b of HIV-infected patients. Clinical Microbiology and Infection, 22(4), 386.e1 - 386.e3. https://doi.org/10.1016/j.cmi.2015.12.007

Distribution of natural resistance to NS3 protease inhibitors in hepatitis C genotype 1a separated into clades 1 and 2 and in genotype 1b of HIV-infected patients. / Bagaglio, S.; Uberti Foppa, Caterina; Messina, E.; Merli, M.; Hasson, H.; Andolina, A.; Galli, A.; Lazzarin, A.; Morsica, Giulia.

In: Clinical Microbiology and Infection, Vol. 22, No. 4, 01.04.2016, p. 386.e1 - 386.e3.

Research output: Contribution to journal › Article › peer-review

Bagaglio, S , Uberti Foppa, C, Messina, E, Merli, M, Hasson, H, Andolina, A, Galli, A, Lazzarin, A & Morsica, G 2016, 'Distribution of natural resistance to NS3 protease inhibitors in hepatitis C genotype 1a separated into clades 1 and 2 and in genotype 1b of HIV-infected patients', Clinical Microbiology and Infection, vol. 22, no. 4, pp. 386.e1 - 386.e3. https://doi.org/10.1016/j.cmi.2015.12.007

Bagaglio, S. ; Uberti Foppa, Caterina ; Messina, E. ; Merli, M. ; Hasson, H. ; Andolina, A. ; Galli, A. ; Lazzarin, A. ; Morsica, Giulia. / Distribution of natural resistance to NS3 protease inhibitors in hepatitis C genotype 1a separated into clades 1 and 2 and in genotype 1b of HIV-infected patients. In: Clinical Microbiology and Infection. 2016 ; Vol. 22, No. 4. pp. 386.e1 - 386.e3.

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abstract = "Naturally occurring resistance-associated variants (RAVs) within the protease domain of hepatitis C virus (HCV) genotype (G) 1a separated into clades 1 and 2, and G1b were investigated in 59 HIV/HCV coinfected patients. RAVs were detected in 10/23 G1a/clade 1 and 1/19 G1b (p 0.0059). A similar frequency of RAVs was found when comparing G1a/clade 2 and G1b (p 0.1672). A cross-resistance to the macrocyclic compounds simeprevir and paritaprevir was detected in two G1a/clade 2 and 1 G1b sequences and none of G1a/clade 1 sequences. The simultaneous characterization of subtype and natural RAVs by population analysis of the NS3 domain by may add important information for anti-HCV treatment strategies including protease inhibitors.",

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