Distribution of neurochemical abnormalities in patients with narcolepsy with cataplexy: An in vivo brain proton MR spectroscopy study

Caterina Tonon, Christian Franceschini, Claudia Testa, David Neil Manners, Francesca Poli, Barbara Mostacci, Emanuel Mignot, Pasquale Montagna, Bruno Barbiroli, Raffaele Lodi, Giuseppe Plazzi

Research output: Contribution to journalArticle

Abstract

Narcolepsy with cataplexy is characterised by excessive daytime sleepiness, sudden drops of muscle tone triggered by emotions, termed cataplexy, disrupted nocturnal sleep and other dissociated rapid eye movement (REM) sleep phenomena. Narcolepsy has been linked to a loss of hypothalamic neurons producing hypocretins, neuropeptides implicated in the regulation of the arousal system. Neuroimaging and neurometabolic studies have shown the pathophysiological involvement of other brain structures such as cerebral cortex and thalamus, but, overall with inconsistent results. We investigated, by using an advanced quantitative MR technique, proton MR spectroscopy (1H-MRS), the distribution of brain neurochemical abnormalities in narcolepsy with cataplexy patients. Single voxel 1H-MRS study was performed in the thalamus, hypothalamus, and parietal-occipital cortex of hypocretin deficient, narcolepsy with cataplexy patients, HLA-DQB1*0602-positive, drug free. No significant changes were detected in the thalamus and parietal-occipital cortex of the patients. On the other hand, the neuronal marker N-acetyl-aspartate was reduced in the hypothalamus of narcolepsy with cataplexy patients compared to controls. These 1H-MRS findings further support that in narcolepsy with cataplexy patients, the hypothalamus is the primary site of neural lesions. The absence of 1H-MRS neurodegenerative changes in the thalamus and cerebral cortex suggests that the abnormalities detected in these brain regions by other neuroimaging techniques are likely of functional nature.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalBrain Research Bulletin
Volume80
Issue number3
DOIs
Publication statusPublished - Sep 28 2009

Fingerprint

Cataplexy
Narcolepsy
Protons
Magnetic Resonance Spectroscopy
Thalamus
Brain
Hypothalamus
Occipital Lobe
Parietal Lobe
Neuroimaging
Cerebral Cortex
Sleep
REM Sleep
Arousal
Neuropeptides
Emotions
Neurons
Muscles
Proton Magnetic Resonance Spectroscopy
Pharmaceutical Preparations

Keywords

  • Cataplexy
  • Narcolepsy
  • Proton MR spectroscopy
  • Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Distribution of neurochemical abnormalities in patients with narcolepsy with cataplexy : An in vivo brain proton MR spectroscopy study. / Tonon, Caterina; Franceschini, Christian; Testa, Claudia; Manners, David Neil; Poli, Francesca; Mostacci, Barbara; Mignot, Emanuel; Montagna, Pasquale; Barbiroli, Bruno; Lodi, Raffaele; Plazzi, Giuseppe.

In: Brain Research Bulletin, Vol. 80, No. 3, 28.09.2009, p. 147-150.

Research output: Contribution to journalArticle

Tonon, Caterina ; Franceschini, Christian ; Testa, Claudia ; Manners, David Neil ; Poli, Francesca ; Mostacci, Barbara ; Mignot, Emanuel ; Montagna, Pasquale ; Barbiroli, Bruno ; Lodi, Raffaele ; Plazzi, Giuseppe. / Distribution of neurochemical abnormalities in patients with narcolepsy with cataplexy : An in vivo brain proton MR spectroscopy study. In: Brain Research Bulletin. 2009 ; Vol. 80, No. 3. pp. 147-150.
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