Distribution of penfluridol in rats and mice

Luisa Airoldi, Franca Marcucci, Emilio Mussini, Silvio Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Penfluridol is a long-lasting neuroleptic drug which accumulates in the adipose tissue of rats and mice. The concentration in this tissue, depending on the time, may be 50-100 times higher than in blood or in brain. Penfluridol does not selectively distribute in various brain areas of rats including hemispheres, striatum, diencephalon, mesencephalon and cerebellum. The concentration of penfluridol in rat brain necessary to exert significant anti-amphetamine activity is around 7 ng/g.

Original languageEnglish
Pages (from-to)291-295
Number of pages5
JournalEuropean Journal of Pharmacology
Volume25
Issue number3
DOIs
Publication statusPublished - 1974

Keywords

  • Anti-amphetamine effect
  • Distribution in rats and mice
  • Neuroleptic drugs
  • Penfluridol

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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