TY - JOUR
T1 - Distribution of the natural killer-related receptor for HLA-C during highly active antiretroviral therapy for human immunodeficiency virus infection
AU - Sirianni, Maria Caterina
AU - Ensoli, Fabrizio
AU - Alario, Cecilia
AU - Fiorelli, Valeria
AU - Sacco, Gianna
AU - Topino, Simone
AU - Iebba, Filippo
AU - Mezzaroma, Ivano
AU - Aiuti, Fernando
PY - 2001
Y1 - 2001
N2 - Receptors interacting with Major Histocompatibility Complex class I molecules have been initially found on the surface of human natural killer (NK) cells, where they deliver inhibitory signals to the lysis, being thus defined killer inhibitory receptors (KIR). Subsequently, they were detected also on the surface of T-CD8+ lymphocytes and are particularly expanded during human immunodeficiency virus (HIV) infection, where they downregulate HIV-specific cytolysis. The expression of KIR recognizing human leukocyte antigen-C alleles was assessed in HIV-infected patients, undergoing highly active antiretroviral therapy (HAART). To this end, the combined expression of CD16/CD56, of CD3 and CD8 as well as of KIR (CD158a and CD158b) surface molecules was analyzed on peripheral blood mononuclear cells by monoclonal antibodies, and flow cytometry. An increase of CD3+CD8+CD158b+ cells was found after 6 months of HAART. This finding may have implications for the regulation of T-cell mediated cytolysis during HAART. Human Immunology 62, 1328-1334 (2001).
AB - Receptors interacting with Major Histocompatibility Complex class I molecules have been initially found on the surface of human natural killer (NK) cells, where they deliver inhibitory signals to the lysis, being thus defined killer inhibitory receptors (KIR). Subsequently, they were detected also on the surface of T-CD8+ lymphocytes and are particularly expanded during human immunodeficiency virus (HIV) infection, where they downregulate HIV-specific cytolysis. The expression of KIR recognizing human leukocyte antigen-C alleles was assessed in HIV-infected patients, undergoing highly active antiretroviral therapy (HAART). To this end, the combined expression of CD16/CD56, of CD3 and CD8 as well as of KIR (CD158a and CD158b) surface molecules was analyzed on peripheral blood mononuclear cells by monoclonal antibodies, and flow cytometry. An increase of CD3+CD8+CD158b+ cells was found after 6 months of HAART. This finding may have implications for the regulation of T-cell mediated cytolysis during HAART. Human Immunology 62, 1328-1334 (2001).
KW - HAART
KW - HIV
KW - HLA
KW - Killer inhibitory receptors
KW - NK cells
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U2 - 10.1016/S0198-8859(01)00355-X
DO - 10.1016/S0198-8859(01)00355-X
M3 - Article
C2 - 11756001
AN - SCOPUS:0035205323
VL - 62
SP - 1328
EP - 1334
JO - Human Immunology
JF - Human Immunology
SN - 0198-8859
IS - 12
ER -