Ditazole and platelets: I. effect of ditazole on in vivo platelet aggregation and bleeding time in rats

G. De Gaetano, A. E. Cavenaghi, L. Stella

Research output: Contribution to journalArticle

Abstract

Ditazole (4, 5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol) is a new drug shown to inhibit prostaglandin release from rat platelets. The present study indicates that ditazole, at doses similar to those inhibiting prostaglandin formation in rat, inhibits in vivo collagen-but not ADP-induced rat platelet aggregation. In addition, ditazole does not prolong the bleeding time in rats, but even tends to shorten it. This effect could be due to the inhibition of prostaglandin formation at the side of the vascular injury produced to induce bleeding.

Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalPathophysiology of Haemostasis and Thrombosis
Volume6
Issue number3
DOIs
Publication statusPublished - 1977

Keywords

  • Acetylsalicylic acid
  • Bleeding time
  • Ditazole
  • Platelet aggregation

ASJC Scopus subject areas

  • Hematology
  • Physiology (medical)

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