Diurnal blood pressure variation and hormonal correlates in fatal familial insomnia

Francesco Portaluppi, Pietro Cortelli, Patrizia Avoni, Luciana Vergnani, Manuela Contin, Paolo Maltoni, Anna Pavani, Emilia Sforza, Ettore C. Degli Uberti, Pierluigi Gambetti, Elio Lugaresi

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Fatal familial insomnia is a prion disease in which a selective thalamic degeneration leads to total sleep deprivation, hypertension, dysautonomia, adrenal overactivity, and impaired motor functions. With patients under continuous recumbency and polysomnographic control, we assessed the changes in the 24-hour patterns of blood pressure, heart rate, plasma catecholamines, corticotropin, and serum cortisol in three patients at different stages of the disease. Six healthy volunteers were used as control subjects. A dominant 24-hour component was detected at rhythm analysis of all variables, both in patients and control subjects. In the patients, the amplitudes gradually decreased as the disease progressed, leading to the obliteration of any significant diurnal variation only in the preterminal stage. A shift in phase corresponded to the loss of the nocturnal fall in blood pressure in an early stage of the disease, when nocturnal bradycardia was still preserved. Plasma cortisol was high and became increasingly elevated, whereas corticotropin remained within normal levels; abnormal nocturnal peaks appeared in their circadian patterns. The disrupted patterns of cortisol and blood pressure preceded the development of hypertension and severe dysautonomia, which in turn were paralleled by increasing catecholamine and heart rate levels. Our data demonstrate that in patients with fatal familial insomnia the changes detectable in the rhythmic component of diurnal blood pressure variability result in a pattern of secondary hypertension. Disturbances in thalamic, pituitary-adrenal, and autonomic functions seem to be involved in mediating these changes.

Original languageEnglish
Pages (from-to)569-576
Number of pages8
JournalHypertension
Volume23
Issue number5
Publication statusPublished - May 1994

Fingerprint

Fatal Familial Insomnia
Blood Pressure
Primary Dysautonomias
Hydrocortisone
Hypertension
Adrenocorticotropic Hormone
Catecholamines
Heart Rate
Prion Diseases
Sleep Deprivation
Bradycardia
Healthy Volunteers
Serum

Keywords

  • adrenocorticotropic hormone
  • catecholamines
  • circadian rhythm
  • dysautonomia, familial
  • hydrocortisone

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Portaluppi, F., Cortelli, P., Avoni, P., Vergnani, L., Contin, M., Maltoni, P., ... Lugaresi, E. (1994). Diurnal blood pressure variation and hormonal correlates in fatal familial insomnia. Hypertension, 23(5), 569-576.

Diurnal blood pressure variation and hormonal correlates in fatal familial insomnia. / Portaluppi, Francesco; Cortelli, Pietro; Avoni, Patrizia; Vergnani, Luciana; Contin, Manuela; Maltoni, Paolo; Pavani, Anna; Sforza, Emilia; Degli Uberti, Ettore C.; Gambetti, Pierluigi; Lugaresi, Elio.

In: Hypertension, Vol. 23, No. 5, 05.1994, p. 569-576.

Research output: Contribution to journalArticle

Portaluppi, F, Cortelli, P, Avoni, P, Vergnani, L, Contin, M, Maltoni, P, Pavani, A, Sforza, E, Degli Uberti, EC, Gambetti, P & Lugaresi, E 1994, 'Diurnal blood pressure variation and hormonal correlates in fatal familial insomnia', Hypertension, vol. 23, no. 5, pp. 569-576.
Portaluppi, Francesco ; Cortelli, Pietro ; Avoni, Patrizia ; Vergnani, Luciana ; Contin, Manuela ; Maltoni, Paolo ; Pavani, Anna ; Sforza, Emilia ; Degli Uberti, Ettore C. ; Gambetti, Pierluigi ; Lugaresi, Elio. / Diurnal blood pressure variation and hormonal correlates in fatal familial insomnia. In: Hypertension. 1994 ; Vol. 23, No. 5. pp. 569-576.
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