Abstract
The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (
Original language | English |
---|---|
Pages (from-to) | 351-357 |
Number of pages | 7 |
Journal | Nature |
Volume | 529 |
Issue number | 7586 |
DOIs | |
Publication status | Published - Jan 21 2016 |
ASJC Scopus subject areas
- General
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Divergent clonal selection dominates medulloblastoma at recurrence. / Morrissy, A. Sorana; Garzia, Livia; Shih, David J H; Zuyderduyn, Scott; Huang, Xi; Skowron, Patryk; Remke, Marc; Cavalli, Florence M G; Ramaswamy, Vijay; Lindsay, Patricia E.; Jelveh, Salomeh; Donovan, Laura K.; Wang, Xin; Luu, Betty; Zayne, Kory; Li, Yisu; Mayoh, Chelsea; Thiessen, Nina; Mercier, Eloi; Mungall, Karen L.; Ma, Yusanne; Tse, Kane; Zeng, Thomas; Shumansky, Karey; Roth, Andrew J L; Shah, Sohrab; Farooq, Hamza; Kijima, Noriyuki; Holgado, Borja L.; Lee, John J Y; Matan-Lithwick, Stuart; Liu, Jessica; Mack, Stephen C.; Manno, Alex; Michealraj, K. A.; Nor, Carolina; Peacock, John; Qin, Lei; Reimand, Juri; Rolider, Adi; Thompson, Yuan Y.; Wu, Xiaochong; Pugh, Trevor; Ally, Adrian; Bilenky, Mikhail; Butterfield, Yaron S N; Carlsen, Rebecca; Cheng, Young; Chuah, Eric; Corbett, Richard D.; Dhalla, Noreen; He, An; Lee, Darlene; Li, Haiyan I.; Long, William; Mayo, Michael; Plettner, Patrick; Qian, Jenny Q.; Schein, Jacqueline E.; Tam, Angela; Wong, Tina; Birol, Inanc; Zhao, Yongjun; Faria, Claudia C.; Pimentel, José; Nunes, Sofia; Shalaby, Tarek; Grotzer, Michael; Pollack, Ian F.; Hamilton, Ronald L.; Li, Xiao Nan; Bendel, Anne E.; Fults, Daniel W.; Walter, Andrew W.; Kumabe, Toshihiro; Tominaga, Teiji; Collins, V. Peter; Cho, Yoon Jae; Hoffman, Caitlin; Lyden, David; Wisoff, Jeffrey H.; Garvin, James H.; Stearns, Duncan S.; Massimi, Luca; Schüller, Ulrich; Sterba, Jaroslav; Zitterbart, Karel; Puget, Stephanie; Ayrault, Olivier; Dunn, Sandra E.; Tirapelli, Daniela P C; Carlotti, Carlos G.; Wheeler, Helen; Hallahan, Andrew R.; Ingram, Wendy; MacDonald, Tobey J.; Olson, Jeffrey J.; Van Meir, Erwin G.; Lee, Ji Yeoun; Wang, Kyu Chang; Kim, Seung Ki; Cho, Byung Kyu; Pietsch, Torsten; Fleischhack, Gudrun; Tippelt, Stephan; Ra, Young Shin; Bailey, Simon; Lindsey, Janet C.; Clifford, Steven C.; Eberhart, Charles G.; Cooper, Michael K.; Packer, Roger J.; Massimino, Maura; Garre, Maria Luisa; Bartels, Ute; Tabori, Uri; Hawkins, Cynthia E.; Dirks, Peter; Bouffet, Eric; Rutka, James T.; Wechsler-Reya, Robert J.; Weiss, William A.; Collier, Lara S.; Dupuy, Adam J.; Korshunov, Andrey; Jones, David T W; Kool, Marcel; Northcott, Paul A.; Pfister, Stefan M.; Largaespada, David A.; Mungall, Andrew J.; Moore, Richard A.; Jabado, Nada; Bader, Gary D.; Jones, Steven J M; Malkin, David; Marra, Marco A.; Taylor, Michael D.
In: Nature, Vol. 529, No. 7586, 21.01.2016, p. 351-357.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Divergent clonal selection dominates medulloblastoma at recurrence
AU - Morrissy, A. Sorana
AU - Garzia, Livia
AU - Shih, David J H
AU - Zuyderduyn, Scott
AU - Huang, Xi
AU - Skowron, Patryk
AU - Remke, Marc
AU - Cavalli, Florence M G
AU - Ramaswamy, Vijay
AU - Lindsay, Patricia E.
AU - Jelveh, Salomeh
AU - Donovan, Laura K.
AU - Wang, Xin
AU - Luu, Betty
AU - Zayne, Kory
AU - Li, Yisu
AU - Mayoh, Chelsea
AU - Thiessen, Nina
AU - Mercier, Eloi
AU - Mungall, Karen L.
AU - Ma, Yusanne
AU - Tse, Kane
AU - Zeng, Thomas
AU - Shumansky, Karey
AU - Roth, Andrew J L
AU - Shah, Sohrab
AU - Farooq, Hamza
AU - Kijima, Noriyuki
AU - Holgado, Borja L.
AU - Lee, John J Y
AU - Matan-Lithwick, Stuart
AU - Liu, Jessica
AU - Mack, Stephen C.
AU - Manno, Alex
AU - Michealraj, K. A.
AU - Nor, Carolina
AU - Peacock, John
AU - Qin, Lei
AU - Reimand, Juri
AU - Rolider, Adi
AU - Thompson, Yuan Y.
AU - Wu, Xiaochong
AU - Pugh, Trevor
AU - Ally, Adrian
AU - Bilenky, Mikhail
AU - Butterfield, Yaron S N
AU - Carlsen, Rebecca
AU - Cheng, Young
AU - Chuah, Eric
AU - Corbett, Richard D.
AU - Dhalla, Noreen
AU - He, An
AU - Lee, Darlene
AU - Li, Haiyan I.
AU - Long, William
AU - Mayo, Michael
AU - Plettner, Patrick
AU - Qian, Jenny Q.
AU - Schein, Jacqueline E.
AU - Tam, Angela
AU - Wong, Tina
AU - Birol, Inanc
AU - Zhao, Yongjun
AU - Faria, Claudia C.
AU - Pimentel, José
AU - Nunes, Sofia
AU - Shalaby, Tarek
AU - Grotzer, Michael
AU - Pollack, Ian F.
AU - Hamilton, Ronald L.
AU - Li, Xiao Nan
AU - Bendel, Anne E.
AU - Fults, Daniel W.
AU - Walter, Andrew W.
AU - Kumabe, Toshihiro
AU - Tominaga, Teiji
AU - Collins, V. Peter
AU - Cho, Yoon Jae
AU - Hoffman, Caitlin
AU - Lyden, David
AU - Wisoff, Jeffrey H.
AU - Garvin, James H.
AU - Stearns, Duncan S.
AU - Massimi, Luca
AU - Schüller, Ulrich
AU - Sterba, Jaroslav
AU - Zitterbart, Karel
AU - Puget, Stephanie
AU - Ayrault, Olivier
AU - Dunn, Sandra E.
AU - Tirapelli, Daniela P C
AU - Carlotti, Carlos G.
AU - Wheeler, Helen
AU - Hallahan, Andrew R.
AU - Ingram, Wendy
AU - MacDonald, Tobey J.
AU - Olson, Jeffrey J.
AU - Van Meir, Erwin G.
AU - Lee, Ji Yeoun
AU - Wang, Kyu Chang
AU - Kim, Seung Ki
AU - Cho, Byung Kyu
AU - Pietsch, Torsten
AU - Fleischhack, Gudrun
AU - Tippelt, Stephan
AU - Ra, Young Shin
AU - Bailey, Simon
AU - Lindsey, Janet C.
AU - Clifford, Steven C.
AU - Eberhart, Charles G.
AU - Cooper, Michael K.
AU - Packer, Roger J.
AU - Massimino, Maura
AU - Garre, Maria Luisa
AU - Bartels, Ute
AU - Tabori, Uri
AU - Hawkins, Cynthia E.
AU - Dirks, Peter
AU - Bouffet, Eric
AU - Rutka, James T.
AU - Wechsler-Reya, Robert J.
AU - Weiss, William A.
AU - Collier, Lara S.
AU - Dupuy, Adam J.
AU - Korshunov, Andrey
AU - Jones, David T W
AU - Kool, Marcel
AU - Northcott, Paul A.
AU - Pfister, Stefan M.
AU - Largaespada, David A.
AU - Mungall, Andrew J.
AU - Moore, Richard A.
AU - Jabado, Nada
AU - Bader, Gary D.
AU - Jones, Steven J M
AU - Malkin, David
AU - Marra, Marco A.
AU - Taylor, Michael D.
PY - 2016/1/21
Y1 - 2016/1/21
N2 - The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (
AB - The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (
UR - http://www.scopus.com/inward/record.url?scp=84955506668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955506668&partnerID=8YFLogxK
U2 - 10.1038/nature16478
DO - 10.1038/nature16478
M3 - Article
C2 - 26760213
AN - SCOPUS:84955506668
VL - 529
SP - 351
EP - 357
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7586
ER -