Divergent effect of the anaerobic bacteria by-product butyric acid on the immune response

suppression of T-lymphocyte proliferation and stimulation of interleukin-1 beta production.

C. Eftimiadi, P. Stashenko, M. Tonetti, P. E. Mangiante, R. Massara, S. Zupo, M. Ferrarini

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The effects of short-chain fatty acids (SCFA) produced by anaerobic bacteria, namely propionic, butyric and iso-butyric on T-cell proliferation was investigated. A dose-dependent inhibition of both phytohemagglutinin-induced blastogenesis and mixed lymphocyte culture was observed in the millimolar range of SCFA concentrations. The tested SCFA displayed different levels of suppression. The degree of activity was in the following order: butyrate greater than propionate greater than isobutyrate. T-cell inhibition was partially reversed, at least for propionic and isobutyric acids, by increasing the concentration of macrophages in the assay system. Furthermore, butyric acid displayed an interesting biphasic stimulation of monocyte interleukin-1 beta production, a cytokine with a powerful bone-resorbing activity. Since millimolar concentrations of SCFA are present in gingival fluid from periodontal pockets, the observed results support the role of these by-products of anaerobic metabolism in the pathogenesis of periodontal diseases.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalOral Microbiology and Immunology
Volume6
Issue number1
Publication statusPublished - Feb 1991

Fingerprint

Butyric Acid
Anaerobic Bacteria
Volatile Fatty Acids
Lymphocyte Activation
Interleukin-1beta
Isobutyrates
T-Lymphocytes
Propionates
Anaerobiosis
Periodontal Pocket
Butyrates
Periodontal Diseases
Phytohemagglutinins
Monocytes
Macrophages
Cell Proliferation
Lymphocytes
Cytokines

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)
  • Dentistry(all)

Cite this

Divergent effect of the anaerobic bacteria by-product butyric acid on the immune response : suppression of T-lymphocyte proliferation and stimulation of interleukin-1 beta production. / Eftimiadi, C.; Stashenko, P.; Tonetti, M.; Mangiante, P. E.; Massara, R.; Zupo, S.; Ferrarini, M.

In: Oral Microbiology and Immunology, Vol. 6, No. 1, 02.1991, p. 17-23.

Research output: Contribution to journalArticle

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