Abstract
The effects of short-chain fatty acids (SCFA) produced by anaerobic bacteria, namely propionic, butyric and iso-butyric on T-cell proliferation was investigated. A dose-dependent inhibition of both phytohemagglutinin-induced blastogenesis and mixed lymphocyte culture was observed in the millimolar range of SCFA concentrations. The tested SCFA displayed different levels of suppression. The degree of activity was in the following order: butyrate greater than propionate greater than isobutyrate. T-cell inhibition was partially reversed, at least for propionic and isobutyric acids, by increasing the concentration of macrophages in the assay system. Furthermore, butyric acid displayed an interesting biphasic stimulation of monocyte interleukin-1 beta production, a cytokine with a powerful bone-resorbing activity. Since millimolar concentrations of SCFA are present in gingival fluid from periodontal pockets, the observed results support the role of these by-products of anaerobic metabolism in the pathogenesis of periodontal diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 17-23 |
| Number of pages | 7 |
| Journal | Oral Microbiology and Immunology |
| Volume | 6 |
| Issue number | 1 |
| Publication status | Published - Feb 1991 |
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ASJC Scopus subject areas
- Immunology
- Microbiology (medical)
- Dentistry(all)
Cite this
Divergent effect of the anaerobic bacteria by-product butyric acid on the immune response : suppression of T-lymphocyte proliferation and stimulation of interleukin-1 beta production. / Eftimiadi, C.; Stashenko, P.; Tonetti, M.; Mangiante, P. E.; Massara, R.; Zupo, S.; Ferrarini, M.
In: Oral Microbiology and Immunology, Vol. 6, No. 1, 02.1991, p. 17-23.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Divergent effect of the anaerobic bacteria by-product butyric acid on the immune response
T2 - suppression of T-lymphocyte proliferation and stimulation of interleukin-1 beta production.
AU - Eftimiadi, C.
AU - Stashenko, P.
AU - Tonetti, M.
AU - Mangiante, P. E.
AU - Massara, R.
AU - Zupo, S.
AU - Ferrarini, M.
PY - 1991/2
Y1 - 1991/2
N2 - The effects of short-chain fatty acids (SCFA) produced by anaerobic bacteria, namely propionic, butyric and iso-butyric on T-cell proliferation was investigated. A dose-dependent inhibition of both phytohemagglutinin-induced blastogenesis and mixed lymphocyte culture was observed in the millimolar range of SCFA concentrations. The tested SCFA displayed different levels of suppression. The degree of activity was in the following order: butyrate greater than propionate greater than isobutyrate. T-cell inhibition was partially reversed, at least for propionic and isobutyric acids, by increasing the concentration of macrophages in the assay system. Furthermore, butyric acid displayed an interesting biphasic stimulation of monocyte interleukin-1 beta production, a cytokine with a powerful bone-resorbing activity. Since millimolar concentrations of SCFA are present in gingival fluid from periodontal pockets, the observed results support the role of these by-products of anaerobic metabolism in the pathogenesis of periodontal diseases.
AB - The effects of short-chain fatty acids (SCFA) produced by anaerobic bacteria, namely propionic, butyric and iso-butyric on T-cell proliferation was investigated. A dose-dependent inhibition of both phytohemagglutinin-induced blastogenesis and mixed lymphocyte culture was observed in the millimolar range of SCFA concentrations. The tested SCFA displayed different levels of suppression. The degree of activity was in the following order: butyrate greater than propionate greater than isobutyrate. T-cell inhibition was partially reversed, at least for propionic and isobutyric acids, by increasing the concentration of macrophages in the assay system. Furthermore, butyric acid displayed an interesting biphasic stimulation of monocyte interleukin-1 beta production, a cytokine with a powerful bone-resorbing activity. Since millimolar concentrations of SCFA are present in gingival fluid from periodontal pockets, the observed results support the role of these by-products of anaerobic metabolism in the pathogenesis of periodontal diseases.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026112431&partnerID=8YFLogxK
M3 - Article
C2 - 1945479
AN - SCOPUS:0026112431
VL - 6
SP - 17
EP - 23
JO - Oral Microbiology and Immunology
JF - Oral Microbiology and Immunology
SN - 0902-0055
IS - 1
ER -