Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations

O. Corti, S. DiDonato, G. Finocchiaro

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We identified two partially overlapping cDNAs containing divergent 5' sequences of human carnitine acetyltransferase (CAT). cDNA λSM-1400 extends the sequence of peroxisomal CAT, whereas cDNA λSM-1200 creates a new open reading frame encoding a putative mitochondrial leader peptide. An intron is located where sequences diverge, suggesting that mitochondrial, peroxisomal and possibly endoplasmic reticulum CAT mRNAs derive from alternative splicing of the CAT gene.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalBiochemical Journal
Volume303
Issue number1
Publication statusPublished - 1994

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Carnitine O-Acetyltransferase
Alternative Splicing
Complementary DNA
Protein Sorting Signals
Endoplasmic Reticulum
Introns
Open Reading Frames
Genes
Messenger RNA

ASJC Scopus subject areas

  • Biochemistry

Cite this

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abstract = "We identified two partially overlapping cDNAs containing divergent 5' sequences of human carnitine acetyltransferase (CAT). cDNA λSM-1400 extends the sequence of peroxisomal CAT, whereas cDNA λSM-1200 creates a new open reading frame encoding a putative mitochondrial leader peptide. An intron is located where sequences diverge, suggesting that mitochondrial, peroxisomal and possibly endoplasmic reticulum CAT mRNAs derive from alternative splicing of the CAT gene.",
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