Diverging association of reduced glomerular filtration rate and albuminuria with coronary and noncoronary events in patients with type 2 diabetes

The renal insufficiency and cardiovascular events (RIACE) Italian multicenter study

Anna Solini, Giuseppe Penno, Enzo Bonora, Cecilia Fondelli, Emanuela Orsi, Maura Arosio, Roberto Trevisan, Monica Vedovato, Mauro Cignarelli, Francesco Andreozzi, Antonio Nicolucci, Giuseppe Pugliese

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

OBJECTIVE - Although a reduced estimated glomerular filtration rate (eGFR) was shown to be a powerful independent predictor of cardiovascular disease (CVD), other studies suggested that it confers a much lower risk than albuminuria alone, whereas the combination of the two abnormalities is associated with multiplicative risk. This study aimed at assessing the independent association of previous CVD events, either total or by vascular bed, with eGFR and albuminuria and chronic kidney disease (CKD) phenotypes. RESEARCH DESIGN AND METHODS - This cross-sectional study evaluated 15,773 patients with type 2 diabetes from the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study in 19 outpatient diabetes clinics in years 2007-2008. Albuminuria was assessed by immunonephelometry or immunoturbidimetry. GFR was estimated by the simplified Modification of Diet in Renal Disease Study and the Chronic Kidney Disease-Epidemiology Collaboration equation. CKD was defined as an eGFR 2 or micro- or macroalbuminuria. Major acute CVD events were adjudicated based on hospital discharge records or specialist visits. RESULTS - CVD risk increased linearly with eGFR decline and albuminuria and became significant for values 2 and ≥10.5mg/24 h, respectively. Beyond traditional CVD risk factors, total CVD showed an independent association with albuminuria alone (odds ratio 1.20 [95% CI 1.08-1.33]), reduced eGFR alone (1.52 [1.34-1.73]), and both abnormalities (1.90 [1.66-2.19]). However, coronary events were associated predominantly with reduced eGFR alone, whereas cerebrovascular and peripheral events showed a stronger correlation with the albuminuric CKD phenotypes. CONCLUSIONS - These data, although cross-sectional, show that reduced eGFR, irrespective of albuminuria, is associated with significant CVD, particularly in the coronary district.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalDiabetes Care
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Albuminuria
Glomerular Filtration Rate
Type 2 Diabetes Mellitus
Multicenter Studies
Renal Insufficiency
Cardiovascular Diseases
Chronic Renal Insufficiency
Diet Therapy
Phenotype
Hospital Records
Acute Disease
Ambulatory Care Facilities
Blood Vessels
Epidemiology
Research Design
Cross-Sectional Studies
Odds Ratio
Kidney

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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Diverging association of reduced glomerular filtration rate and albuminuria with coronary and noncoronary events in patients with type 2 diabetes : The renal insufficiency and cardiovascular events (RIACE) Italian multicenter study. / Solini, Anna; Penno, Giuseppe; Bonora, Enzo; Fondelli, Cecilia; Orsi, Emanuela; Arosio, Maura; Trevisan, Roberto; Vedovato, Monica; Cignarelli, Mauro; Andreozzi, Francesco; Nicolucci, Antonio; Pugliese, Giuseppe.

In: Diabetes Care, Vol. 35, No. 1, 01.2012, p. 143-149.

Research output: Contribution to journalArticle

Solini, Anna ; Penno, Giuseppe ; Bonora, Enzo ; Fondelli, Cecilia ; Orsi, Emanuela ; Arosio, Maura ; Trevisan, Roberto ; Vedovato, Monica ; Cignarelli, Mauro ; Andreozzi, Francesco ; Nicolucci, Antonio ; Pugliese, Giuseppe. / Diverging association of reduced glomerular filtration rate and albuminuria with coronary and noncoronary events in patients with type 2 diabetes : The renal insufficiency and cardiovascular events (RIACE) Italian multicenter study. In: Diabetes Care. 2012 ; Vol. 35, No. 1. pp. 143-149.
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abstract = "OBJECTIVE - Although a reduced estimated glomerular filtration rate (eGFR) was shown to be a powerful independent predictor of cardiovascular disease (CVD), other studies suggested that it confers a much lower risk than albuminuria alone, whereas the combination of the two abnormalities is associated with multiplicative risk. This study aimed at assessing the independent association of previous CVD events, either total or by vascular bed, with eGFR and albuminuria and chronic kidney disease (CKD) phenotypes. RESEARCH DESIGN AND METHODS - This cross-sectional study evaluated 15,773 patients with type 2 diabetes from the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study in 19 outpatient diabetes clinics in years 2007-2008. Albuminuria was assessed by immunonephelometry or immunoturbidimetry. GFR was estimated by the simplified Modification of Diet in Renal Disease Study and the Chronic Kidney Disease-Epidemiology Collaboration equation. CKD was defined as an eGFR 2 or micro- or macroalbuminuria. Major acute CVD events were adjudicated based on hospital discharge records or specialist visits. RESULTS - CVD risk increased linearly with eGFR decline and albuminuria and became significant for values 2 and ≥10.5mg/24 h, respectively. Beyond traditional CVD risk factors, total CVD showed an independent association with albuminuria alone (odds ratio 1.20 [95{\%} CI 1.08-1.33]), reduced eGFR alone (1.52 [1.34-1.73]), and both abnormalities (1.90 [1.66-2.19]). However, coronary events were associated predominantly with reduced eGFR alone, whereas cerebrovascular and peripheral events showed a stronger correlation with the albuminuric CKD phenotypes. CONCLUSIONS - These data, although cross-sectional, show that reduced eGFR, irrespective of albuminuria, is associated with significant CVD, particularly in the coronary district.",
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T2 - The renal insufficiency and cardiovascular events (RIACE) Italian multicenter study

AU - Solini, Anna

AU - Penno, Giuseppe

AU - Bonora, Enzo

AU - Fondelli, Cecilia

AU - Orsi, Emanuela

AU - Arosio, Maura

AU - Trevisan, Roberto

AU - Vedovato, Monica

AU - Cignarelli, Mauro

AU - Andreozzi, Francesco

AU - Nicolucci, Antonio

AU - Pugliese, Giuseppe

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