Diverse clinical outcomes of eosinophilic patients with t-cell receptor gene rearrangements: The emerging diagnostic importance of molecular genetics testing

Joel L. Moake, J. Evan Sadler, Pier Mannucci, Pankaj Ganguly

Research output: Contribution to journalArticle

Abstract

Abnormal clones of clusters of differentiation (CD)3 -CD4 + or CD3 +CD4 -CD8 - phenotypically abnormal lymphocytes have been identified in some patients who have the idiopathic hypereosinophilic syndrome. This report illustrates the disparate clinical courses of six eosinophilic patients with evidence of abnormal T-cell clones based on the finding of a T-cell receptor gene rearrangement. The data suggest that molecular genetics testing for T-cell receptor gene rearrangements should be included in the routine work-up of patients with idiopathic eosinophilia.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalAmerican Journal of Hematology
Volume68
Issue number2
DOIs
Publication statusPublished - 2001

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Keywords

  • Hypereosinophilia
  • Lymphoma
  • T-cell receptor

ASJC Scopus subject areas

  • Hematology

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