Diverse clinical outcomes of eosinophilic patients with t-cell receptor gene rearrangements

The emerging diagnostic importance of molecular genetics testing

Joel L. Moake, J. Evan Sadler, Pier Mannucci, Pankaj Ganguly

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Abnormal clones of clusters of differentiation (CD)3 -CD4 + or CD3 +CD4 -CD8 - phenotypically abnormal lymphocytes have been identified in some patients who have the idiopathic hypereosinophilic syndrome. This report illustrates the disparate clinical courses of six eosinophilic patients with evidence of abnormal T-cell clones based on the finding of a T-cell receptor gene rearrangement. The data suggest that molecular genetics testing for T-cell receptor gene rearrangements should be included in the routine work-up of patients with idiopathic eosinophilia.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalAmerican Journal of Hematology
Volume68
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Gene Rearrangement
Genetic Testing
T-Lymphocyte Gene Rearrangement
T-Cell Receptor Genes
Molecular Biology
Clone Cells
Hypereosinophilic Syndrome
Eosinophilia
Lymphocytes
T-Lymphocytes

Keywords

  • Hypereosinophilia
  • Lymphoma
  • T-cell receptor

ASJC Scopus subject areas

  • Hematology

Cite this

Diverse clinical outcomes of eosinophilic patients with t-cell receptor gene rearrangements : The emerging diagnostic importance of molecular genetics testing. / Moake, Joel L.; Evan Sadler, J.; Mannucci, Pier; Ganguly, Pankaj.

In: American Journal of Hematology, Vol. 68, No. 2, 2001, p. 81-86.

Research output: Contribution to journalArticle

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