Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease

Paola Briata, Domenico Bordo, Margherita Puppo, Franco Gorlero, Martina Rossi, Nora Perrone-Bizzozero, Roberto Gherzi

Research output: Contribution to journalArticlepeer-review

Abstract

The single-stranded nucleic acid-binding protein KHSRP (KH-type splicing regulatory protein) modulates RNA life and gene expression at various levels. KHSRP controls important cellular functions as different as proliferation, differentiation, metabolism, and response to infectious agents. We summarize and discuss experimental evidence providing a potential link between changes in KHSRP expression/function and human diseases including neuromuscular disorders, obesity, type II diabetes, and cancer.

Original languageEnglish
Pages (from-to)227-240
Number of pages14
JournalWiley Interdisciplinary Reviews: RNA
Volume7
Issue number2
DOIs
Publication statusPublished - Mar 1 2016

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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