Diving into the blue

In vivo microscopic characterization of the dermoscopic blue hue

Giovanni Pellacani, Sara Bassoli, Caterina Longo, Anna Maria Cesinaro, Stefania Seidenari

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: In dermoscopy the presence of a blue hue is a clue for malignancy, although a blue tint is sometimes observable in benign lesions. Objective: To identify the in vivo confocal microscopy correlates of the blue hue for improving diagnostic accuracy for melanoma. Methods: Fifty-seven melanomas, 41 junctional, 88 compound, and 27 Spitz nevi were studied by dermoscopy, confocal microscopy, and histopathology. Results: Confocal microscopy enabled the distinction between blue areas and blue veil, the former characterized by plump cells corresponding to melanophages and inflammatory infiltrate at histology, the latter by the contemporary presence of epidermal and dermal features consistent with diagnosis of melanoma, such as disarranged pattern, pagetoid cells, cytologic and architectural atypias, nonhomogeneous and cerebriform clusters, and dermal nucleated cells. Limitations: Confocal microscopy failed to accurately distinguish Spitz nevi, because of the presence of cytoarchitectural disarray in the epidermis and the upper dermis. Conclusion: Confocal microscopy enabled the in vivo identification of characteristic cytological substrates correlated with the blue features in dermoscopy.

Original languageEnglish
Pages (from-to)96-104
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume57
Issue number1
DOIs
Publication statusPublished - Jul 2007

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Diving
Confocal Microscopy
Dermoscopy
Epithelioid and Spindle Cell Nevus
Melanoma
Skin
Dermis
Epidermis
Histology
Neoplasms

ASJC Scopus subject areas

  • Dermatology

Cite this

Diving into the blue : In vivo microscopic characterization of the dermoscopic blue hue. / Pellacani, Giovanni; Bassoli, Sara; Longo, Caterina; Cesinaro, Anna Maria; Seidenari, Stefania.

In: Journal of the American Academy of Dermatology, Vol. 57, No. 1, 07.2007, p. 96-104.

Research output: Contribution to journalArticle

Pellacani, Giovanni ; Bassoli, Sara ; Longo, Caterina ; Cesinaro, Anna Maria ; Seidenari, Stefania. / Diving into the blue : In vivo microscopic characterization of the dermoscopic blue hue. In: Journal of the American Academy of Dermatology. 2007 ; Vol. 57, No. 1. pp. 96-104.
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