DLX genes as targets of ALL-1: DLX 2,3,4 down-regulation in t(4;11) acute lymphoblastic leukemias

Nicoletta Ferrari, Giulio L. Palmisano, Laura Paleari, Giuseppe Basso, Manuela Mangioni, Vincenzo Fidanza, Adriana Albini, Carlo M. Croce, Giovanni Levi, Claudio Brigati

Research output: Contribution to journalArticlepeer-review

Abstract

Dlx genes constitute a gene family thought to be essential in morphogenesis and development. We show here that in vertebrate cells, Dlx genes appear to be part of a regulatory cascade initiated by acute lymphoblastic leukemia (ALL)-1, a master regulator gene whose disruption is implicated in several human acute leukemias. The expression of Dlx2, Dlx3, Dlx5, Dlx6, and Dlx7 was absent in All-1 -/- mouse embryonic stem cells and reduced in All-1 +/- cells. In leukemic patients affected by the t(4;11)(q21;q23) chromosomal abnormality, the expression of DLX2, DLX3, and DLX4 was virtually abrogated. Our data indicate that Dlx genes are downstream targets of ALL-1 and could be considered as important tools for the study of the early leukemic cell phenotype.

Original languageEnglish
Pages (from-to)302-305
Number of pages4
JournalJournal of Leukocyte Biology
Volume74
Issue number2
DOIs
Publication statusPublished - Aug 2003

Keywords

  • ES cells
  • HOM-C
  • RT-PCR
  • Trithorax

ASJC Scopus subject areas

  • Cell Biology

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