DMSO-induced changes in the procoagulant and fibrinolytic activity of B16 melanoma cells: Influence on lung colony formation

Bruno Casali, Maria Grazia Lampugnani, Monica Riganti, Anna Niewiarowska, Grazia Alessio, Luciana Mussoni, Nicola Semeraro, Maria Benedetta Donati

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Abstract

In this study DMSO (dimethylsulphoxide) was used as a tool to test the significance of in vitro modifications of procoagulant and fibrinolytic activity of tumor cells for their in vivo metastatic ability. Bl6 melanoma cells were chosen as the experimental model. After four days' treatment DMSO increased both the procoagulant and fibrinolytic (plasminogen activator) activity of B16 melanoma cells in a dose-related manner. DMSO treated cells showed significantly greater lung colonizing ability than untreated cells. Our results indicate that DMSO treatment in vitro can modulate procoagulant and fibrinolytic activity and the metastatic ability of B16 melanoma cells; however a direct causal relationship between these in vitro and in vivo effects remains to be established.

Original languageEnglish
Pages (from-to)377-385
Number of pages9
JournalClinical & Experimental Metastasis
Volume6
Issue number5
DOIs
Publication statusPublished - Sep 1988

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ASJC Scopus subject areas

  • Cancer Research

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