DNA and cell death

D. Monti, L. Troiano, F. Tropea, E. Grassilli, A. Cossarizza, D. Barozzi, S. Bettuzzi, A. Corti, C. Franceschi

Research output: Contribution to journalArticle

Abstract

The type of DNA damage and the role of poly (ADP-ribosyl) polymerase (ADPRP) and sulphated glyprotein 2 (SGP-2) in programmed cell death (apoptosis) was investigated in the following model systems: i) rat thymocytes treated with dexamethasone (DEX) either in vitro or in vivo; ii) human perypheral blood mononuclear cells (hPBMCs) exposed to oxygen free radicals (OR); iii) K562 cell line killed by hPBCs during spontaneous (NK) or interleukin-2 (IL-2)-induced (LAK) cytotoxic activity. The results suggest that ADPRP and SGP-2 are involved in the apoptotic process, but their role probably differs according to the type of cell and the inducing damage/stimulus. Moreover, no simple correlation appears to exist between the extent of DNA damage and cell survival or cell death.

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalCytotechnology
Volume5
Issue number1 Supplement
DOIs
Publication statusPublished - Feb 1991

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ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Biotechnology

Cite this

Monti, D., Troiano, L., Tropea, F., Grassilli, E., Cossarizza, A., Barozzi, D., Bettuzzi, S., Corti, A., & Franceschi, C. (1991). DNA and cell death. Cytotechnology, 5(1 Supplement), 74-77. https://doi.org/10.1007/BF00736814