DNA and cell death

D. Monti, L. Troiano, F. Tropea, E. Grassilli, A. Cossarizza, D. Barozzi, S. Bettuzzi, A. Corti, C. Franceschi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The type of DNA damage and the role of poly (ADP-ribosyl) polymerase (ADPRP) and sulphated glyprotein 2 (SGP-2) in programmed cell death (apoptosis) was investigated in the following model systems: i) rat thymocytes treated with dexamethasone (DEX) either in vitro or in vivo; ii) human perypheral blood mononuclear cells (hPBMCs) exposed to oxygen free radicals (OR); iii) K562 cell line killed by hPBCs during spontaneous (NK) or interleukin-2 (IL-2)-induced (LAK) cytotoxic activity. The results suggest that ADPRP and SGP-2 are involved in the apoptotic process, but their role probably differs according to the type of cell and the inducing damage/stimulus. Moreover, no simple correlation appears to exist between the extent of DNA damage and cell survival or cell death.

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalCytotechnology
Volume5
Issue number1 Supplement
DOIs
Publication statusPublished - Feb 1991

Fingerprint

Cell death
Adenosine Diphosphate
DNA Damage
Administrative data processing
DNA
Cell Death
Cells
K562 Cells
Thymocytes
Dexamethasone
Free Radicals
Interleukin-2
Rats
Reactive Oxygen Species
Blood Cells
Cell Survival
Blood
Apoptosis
Oxygen
Free radicals

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Biotechnology

Cite this

Monti, D., Troiano, L., Tropea, F., Grassilli, E., Cossarizza, A., Barozzi, D., ... Franceschi, C. (1991). DNA and cell death. Cytotechnology, 5(1 Supplement), 74-77. https://doi.org/10.1007/BF00736814

DNA and cell death. / Monti, D.; Troiano, L.; Tropea, F.; Grassilli, E.; Cossarizza, A.; Barozzi, D.; Bettuzzi, S.; Corti, A.; Franceschi, C.

In: Cytotechnology, Vol. 5, No. 1 Supplement, 02.1991, p. 74-77.

Research output: Contribution to journalArticle

Monti, D, Troiano, L, Tropea, F, Grassilli, E, Cossarizza, A, Barozzi, D, Bettuzzi, S, Corti, A & Franceschi, C 1991, 'DNA and cell death', Cytotechnology, vol. 5, no. 1 Supplement, pp. 74-77. https://doi.org/10.1007/BF00736814
Monti D, Troiano L, Tropea F, Grassilli E, Cossarizza A, Barozzi D et al. DNA and cell death. Cytotechnology. 1991 Feb;5(1 Supplement):74-77. https://doi.org/10.1007/BF00736814
Monti, D. ; Troiano, L. ; Tropea, F. ; Grassilli, E. ; Cossarizza, A. ; Barozzi, D. ; Bettuzzi, S. ; Corti, A. ; Franceschi, C. / DNA and cell death. In: Cytotechnology. 1991 ; Vol. 5, No. 1 Supplement. pp. 74-77.
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