DNA bacterial load in children with bacteremic pneumococcal community-acquired pneumonia

S. Esposito; A. Marchese; A. E. Tozzi; G. A. Rossi; L. Da Dalt; G. Bona; C. Pelucchi; G. C. Schito; N. Principi

doi:10.1007/s10096-013-1821-0

DNA bacterial load in children with bacteremic pneumococcal community-acquired pneumonia

S. Esposito, A. Marchese, A. E. Tozzi, G. A. Rossi, L. Da Dalt, G. Bona, C. Pelucchi, G. C. Schito, N. Principi

Research output: Contribution to journal › Article › peer-review

Abstract

This study was conducted to evaluate the association between pneumococcal DNA load and parapneumonic pleural effusion (PPE) in children with community-acquired pneumonia. Bacterial load was quantified and related to the presence of PPE with or without empyema in 72 otherwise healthy children aged ≤5 years who were hospitalised because of radiographically confirmed CAP and showed a real-time polymerase chain reaction that was positive for Streptococcus pneumoniae. The proportion of children with a high bacterial load (i.e. ≥265 DNA copies/mL) was larger among the subjects with PPE than those without it. Multivariate analysis showed that a high bacterial load was significantly associated with PPE (OR 8.65; 95 % CI 1.10-67.8 vs a bacterial load of

Original language	English
Pages (from-to)	877-881
Number of pages	5
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	32
Issue number	7
DOIs	https://doi.org/10.1007/s10096-013-1821-0
Publication status	Published - Jul 2013

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1007/s10096-013-1821-0

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title = "DNA bacterial load in children with bacteremic pneumococcal community-acquired pneumonia",

abstract = "This study was conducted to evaluate the association between pneumococcal DNA load and parapneumonic pleural effusion (PPE) in children with community-acquired pneumonia. Bacterial load was quantified and related to the presence of PPE with or without empyema in 72 otherwise healthy children aged ≤5 years who were hospitalised because of radiographically confirmed CAP and showed a real-time polymerase chain reaction that was positive for Streptococcus pneumoniae. The proportion of children with a high bacterial load (i.e. ≥265 DNA copies/mL) was larger among the subjects with PPE than those without it. Multivariate analysis showed that a high bacterial load was significantly associated with PPE (OR 8.65; 95 % CI 1.10-67.8 vs a bacterial load of ",

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T1 - DNA bacterial load in children with bacteremic pneumococcal community-acquired pneumonia

AU - Esposito, S.

AU - Marchese, A.

AU - Tozzi, A. E.

AU - Rossi, G. A.

AU - Da Dalt, L.

AU - Bona, G.

AU - Pelucchi, C.

AU - Schito, G. C.

AU - Principi, N.

PY - 2013/7

Y1 - 2013/7

N2 - This study was conducted to evaluate the association between pneumococcal DNA load and parapneumonic pleural effusion (PPE) in children with community-acquired pneumonia. Bacterial load was quantified and related to the presence of PPE with or without empyema in 72 otherwise healthy children aged ≤5 years who were hospitalised because of radiographically confirmed CAP and showed a real-time polymerase chain reaction that was positive for Streptococcus pneumoniae. The proportion of children with a high bacterial load (i.e. ≥265 DNA copies/mL) was larger among the subjects with PPE than those without it. Multivariate analysis showed that a high bacterial load was significantly associated with PPE (OR 8.65; 95 % CI 1.10-67.8 vs a bacterial load of

AB - This study was conducted to evaluate the association between pneumococcal DNA load and parapneumonic pleural effusion (PPE) in children with community-acquired pneumonia. Bacterial load was quantified and related to the presence of PPE with or without empyema in 72 otherwise healthy children aged ≤5 years who were hospitalised because of radiographically confirmed CAP and showed a real-time polymerase chain reaction that was positive for Streptococcus pneumoniae. The proportion of children with a high bacterial load (i.e. ≥265 DNA copies/mL) was larger among the subjects with PPE than those without it. Multivariate analysis showed that a high bacterial load was significantly associated with PPE (OR 8.65; 95 % CI 1.10-67.8 vs a bacterial load of

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DNA bacterial load in children with bacteremic pneumococcal community-acquired pneumonia

Abstract

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