DNA bacterial load in children with bacteremic pneumococcal community-acquired pneumonia

S. Esposito, A. Marchese, A. E. Tozzi, G. A. Rossi, L. Da Dalt, G. Bona, C. Pelucchi, G. C. Schito, N. Principi

Research output: Contribution to journalArticlepeer-review


This study was conducted to evaluate the association between pneumococcal DNA load and parapneumonic pleural effusion (PPE) in children with community-acquired pneumonia. Bacterial load was quantified and related to the presence of PPE with or without empyema in 72 otherwise healthy children aged ≤5 years who were hospitalised because of radiographically confirmed CAP and showed a real-time polymerase chain reaction that was positive for Streptococcus pneumoniae. The proportion of children with a high bacterial load (i.e. ≥265 DNA copies/mL) was larger among the subjects with PPE than those without it. Multivariate analysis showed that a high bacterial load was significantly associated with PPE (OR 8.65; 95 % CI 1.10-67.8 vs a bacterial load of

Original languageEnglish
Pages (from-to)877-881
Number of pages5
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Issue number7
Publication statusPublished - Jul 2013

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'DNA bacterial load in children with bacteremic pneumococcal community-acquired pneumonia'. Together they form a unique fingerprint.

Cite this