Valutazione del danno e del riparo del DNA indotti dal trattamento in vivo con benzidina.

C. Bolognesi; C. F. Cesarone; L. Santi

Valutazione del danno e del riparo del DNA indotti dal trattamento in vivo con benzidina.

Translated title of the contribution: DNA damage and repair induced in vivo by benzidine treatment

C. Bolognesi, C. F. Cesarone, L. Santi

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

DNA damage was evaluated in kidney and liver of mice treated with benzidine at the dose of 150 mg/Kg. The data presented show that the liver can be considered as the target tissue more influenced by the benzidine metabolites. The maxima of DNA fragmentation in the liver and kidney were at 4 and 2 hours respectively after treatment. Moreover the induced DNA damage in kidney and liver of mice treated was evaluated in the time depending from the rate of repair synthesis.

Translated title of the contribution	DNA damage and repair induced in vivo by benzidine treatment
Original language	Italian
Pages (from-to)	1673-1679
Number of pages	7
Journal	Bollettino della Societa Italiana di Biologia Sperimentale
Volume	56
Issue number	16
Publication status	Published - Aug 30 1980

ASJC Scopus subject areas

Medicine(all)

Cite this

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abstract = "DNA damage was evaluated in kidney and liver of mice treated with benzidine at the dose of 150 mg/Kg. The data presented show that the liver can be considered as the target tissue more influenced by the benzidine metabolites. The maxima of DNA fragmentation in the liver and kidney were at 4 and 2 hours respectively after treatment. Moreover the induced DNA damage in kidney and liver of mice treated was evaluated in the time depending from the rate of repair synthesis.",

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AU - Bolognesi, C.

AU - Cesarone, C. F.

AU - Santi, L.

PY - 1980/8/30

Y1 - 1980/8/30

N2 - DNA damage was evaluated in kidney and liver of mice treated with benzidine at the dose of 150 mg/Kg. The data presented show that the liver can be considered as the target tissue more influenced by the benzidine metabolites. The maxima of DNA fragmentation in the liver and kidney were at 4 and 2 hours respectively after treatment. Moreover the induced DNA damage in kidney and liver of mice treated was evaluated in the time depending from the rate of repair synthesis.

AB - DNA damage was evaluated in kidney and liver of mice treated with benzidine at the dose of 150 mg/Kg. The data presented show that the liver can be considered as the target tissue more influenced by the benzidine metabolites. The maxima of DNA fragmentation in the liver and kidney were at 4 and 2 hours respectively after treatment. Moreover the induced DNA damage in kidney and liver of mice treated was evaluated in the time depending from the rate of repair synthesis.

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ER -

Valutazione del danno e del riparo del DNA indotti dal trattamento in vivo con benzidina.

Abstract

ASJC Scopus subject areas

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