DNA damage and TNFα cytokine production in hairdressers with contact dermatitis

Delia Cavallo, Cinzia Lucia Ursini, Andrea Setini, Concetta Chianese, Antonio Cristaudo, Sergio Iavicoli

Research output: Contribution to journalArticlepeer-review


The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase) modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalContact Dermatitis
Issue number3
Publication statusPublished - Sep 2005


  • Direct-oxidative DNA damage
  • Hairdressers
  • Hand dermatitis
  • TNFα

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology


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