Abstract
The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase) modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (
Original language | English |
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Pages (from-to) | 125-129 |
Number of pages | 5 |
Journal | Contact Dermatitis |
Volume | 53 |
Issue number | 3 |
DOIs | |
Publication status | Published - Sep 2005 |
Keywords
- Direct-oxidative DNA damage
- Hairdressers
- Hand dermatitis
- TNFα
ASJC Scopus subject areas
- Dermatology
- Toxicology
- Immunology