DNA damage associated with ultrastructural alterations in rat myocardium after loud noise exposure

Paola Lenzi, Giada Frenzili, Marco Gesi, Michela Ferrucci, Gloria Lazzeri, Francesco Fornai, Macro Nigro

Research output: Contribution to journalArticlepeer-review

Abstract

Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyocytes. The exposure to loud noise (100 dBA) for 12 hr caused a significant increase of DNA damage, accompanied by swelling of mitochondrial membranes, dilution of the matrix, and cristolysis. These alterations were concomitant with increased in situ noradrenaline levels and utilization. Genetic and ultrastructural alterations did not decrease 24 hr after the cessation of the stimulus. An elevated oxyradical generation, possibly related to altered sympathetic innervation, is hypothesized as responsible for the induction and persistence of noise-induced cellular damage.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalEnvironmental Health Perspectives
Volume111
Issue number4
Publication statusPublished - Apr 1 2003

Keywords

  • Comet assay
  • DNA damage
  • Loud noise
  • Mitochondria
  • Myocardium
  • Rat

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

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